Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity
| Autor: | Patricio Giralt Muiña, Juan Giralt Muiña, A. Alberto León Martín, M. José Ballester Herrera, Rafael Ruiz Cano, Enrique Palomo Atance |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Lipoproteins medicine.medical_treatment Blood Pressure Overweight Sampling Studies Insulin resistance Internal medicine Diabetes mellitus medicine Humans Insulin Obesity Prospective Studies Child Glycated Hemoglobin Metabolic Syndrome Type 1 diabetes Anthropometry Waist-Hip Ratio business.industry nutritional and metabolic diseases medicine.disease Lipids Cross-Sectional Studies Diabetes Mellitus Type 1 Glucose Endocrinology Child Preschool Hypertension Female Insulin Resistance medicine.symptom Metabolic syndrome business Body mass index |
| Zdroj: | Endocrinología y Nutrición (English Edition). 60:379-385 |
| ISSN: | 2173-5093 |
| Popis: | To assess the estimated glucose disposal rate (eGDR), insulin dose, and lipoprotein profile in children with type 1 diabetes mellitus (T1DM) and overweight or obesity as compared to children with T1DM and normal weight.A total of 115 patients (aged 5-16 years) with T1DM on intensive insulin therapy were recruited. The following parameters were measured: weight, height, body mass index, waist and hip circumference, insulin dose, eGDR, glycosylated hemoglobin, blood pressure, and lipoprotein profile. Results were stratified by sex and age.No significant differences were found in eGDR between children with normal weight, overweight, and obesity. However, obese children older than 11 years had lower eGDR values (9.3±1.3 vs 10.1±0.8 mg kg(-1)min(-1); p0.01). Insulin dose was higher in overweight and obese children, especially in IU/m2/day (37.7 vs 36.1 vs. 29.4 respectively; p0.01). Obese children had higher low-density lipoprotein cholesterol levels than children with overweight and normal weight (106.5 vs 91.7 vs 91.5mg/dL respectively; p0.01). No correlation was found between waist circumference and the different markers of insulin resistance.Values of eGDR values were lower in obese children with T1DM older than 11 years, and this may therefore be considered a marker of insulin resistance. Insulin dose was higher in diabetic patients with overweight or obesity, specially in IU/m2/day. Obese children with T1DM had a lipoprotein profile of cardiovascular risk. |
| Databáze: | OpenAIRE |
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