Evidence supporting an association between the DRB1 gene and schizophrenia in Japanese
| Autor: | Hideo Hamaguchi, Hitoshi Shibuya, Hiromitsu Shimizu, Atsushi Iwawaki, J Aoki, Tadao Arinami, Yoshiro Okubo, H. Tagaya, Masanari Itokawa, S. Yano, Y Otsuka, H. Enguchi, Michio Toru, Katsuya Ota |
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| Rok vydání: | 1998 |
| Předmět: |
Male
musculoskeletal diseases Oncology medicine.medical_specialty Psychosis Genotype Genetic determinism Japan immune system diseases Polymorphism (computer science) Internal medicine mental disorders HLA-DR4 Antigen medicine Humans Allele skin and connective tissue diseases HLA-DRB1 Biological Psychiatry Genetics HLA-DR1 Antigen HLA-DR Antigens Odds ratio Middle Aged medicine.disease Psychiatry and Mental health Phenotype Schizophrenia Female Psychology HLA-DRB1 Chains |
| Zdroj: | Schizophrenia Research. 32:81-86 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/s0920-9964(98)00047-4 |
| Popis: | The authors attempted a replication of earlier studies that detected an association of HLA-DR4 and DR1 with schizophrenia. Japanese patients with schizophrenia (n = 266, DSM-III-R criteria) and Japanese controls (n = 283) were genotyped for DR1 and DR4 alleles using a combination of group-specific polymerase chain reaction (PCR) amplification and PCR-restriction fragment length polymorphism. Significant positive association with HLA-DR1 [odds ratio (OR) = 1.87, corrected p = 0.04] and a negative association with HLA-DR4 (OR = 0.63, corrected p = 0.02) was noted. DR1 and DR4 were independently associated with schizophrenia. The association of the DR1-positive/DR4-negative genotype with schizophrenia was modest (OR = 2.60, 95% confidence intervals = 1.38-4.89, corrected p = 0.008). Thus, these findings support an association of the HLA DRB1 gene locus with schizophrenia in the Japanese population. Since both DR4 and DR1 are positively associated with rheumatoid arthritis, our findings are not simply consistent with the known negative association between schizophrenia and rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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