Selective Hippocampal Lesions Do Not Increase Adrenocortical Activity
| Autor: | Hill-Aina Steffenach, Robert Murison, Frode A. Tuvnes, May-Britt Moser, Edvard I. Moser |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Behavioral/Systems/Cognitive Hippocampal formation Inhibitory postsynaptic potential Hippocampus Nucleus Accumbens Stereotaxic Techniques chemistry.chemical_compound Corticosterone Internal medicine Excitatory Amino Acid Agonists medicine Animals Learning Rats Long-Evans Ibotenic Acid Neurons Brain Mapping Electroshock Infusions Intralesional Muscimol Chemistry GABAA receptor General Neuroscience Subiculum Rats Cold Temperature Endocrinology nervous system Stereotaxic technique Adrenal Cortex Stress Psychological |
| Zdroj: | The Journal of Neuroscience. 23:4345-4354 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.23-10-04345.2003 |
| Popis: | It has been proposed that the hippocampus exerts a tonic inhibitory influence on the hypothalamic–pituitary–adrenal (HPA) stress axis. This claim rests, in particular, on the upregulation of corticosterone secretion and other measures of HPA activity after nonselective lesions of the hippocampal formation. We measured plasma corticosterone concentrations after selective neurotoxic damage to the hippocampus and the subiculum in rats. Concentrations were estimated during rest in the rat's home cage and at several time points after varying degrees of stress. Lesions of the hippocampus did not increase the concentration of corticosterone relative to control rats in any condition. Temporary inactivation of the hippocampus or the ventral subiculum by infusion of the GABAAreceptor agonist muscimol also failed to induce hypersecretion, although hippocampal infusions did impair spatial memory. These results suggest that the hippocampus is not necessary for tonic inhibition of adrenocortical activity and imply that the HPA axis receives efficient negative feedback inhibition from other brain systems too. |
| Databáze: | OpenAIRE |
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