Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines
| Autor: | Zheng Quan, Nanqun Zhu, Kan He, Ching Shu Lai, Li Zhang, Chi-Tang Ho, Qun Yi Zheng, Min-Hsiung Pan, Naisheng Bai, Zhu Zhou |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Flowers Pharmacognosy Sesquiterpene Analytical Chemistry chemistry.chemical_compound Lactones Cell Line Tumor Drug Discovery Humans Cytotoxicity Pharmacology chemistry.chemical_classification Plants Medicinal biology Molecular Structure Organic Chemistry Biological activity biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Complementary and alternative medicine Inula britannica chemistry Biochemistry Cancer cell Molecular Medicine Inula Drug Screening Assays Antitumor Sesquiterpenes Lactone Drugs Chinese Herbal |
| Zdroj: | Journal of natural products. 69(4) |
| ISSN: | 0163-3864 |
| Popis: | Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays. |
| Databáze: | OpenAIRE |
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