An Enzyme-Linked Immunosorbent Assay (ELISA) for the Measurement of Activated Factor XII (Hageman Factor) in Human Plasma
| Autor: | Burgess Ai, Ford Rp, Esnouf Mp, Sarphie A |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
animal structures
medicine.drug_class Immunology Enzyme-Linked Immunosorbent Assay Monoclonal antibody medicine.disease_cause Cross-reactivity Drug Stability Antibody Specificity Pregnancy Zymogen Freezing Blood plasma medicine Humans cardiovascular diseases Pharmacology Factor XII biology Chemistry Antibodies Monoclonal Molecular biology Coagulation Monoclonal biology.protein Female Antibody circulatory and respiratory physiology |
| Zdroj: | Journal of Immunoassay. 17:119-131 |
| ISSN: | 0197-1522 |
| DOI: | 10.1080/01971529608005783 |
| Popis: | A direct enzyme-linked immunosorbent assay (ELISA) employing 2/215 mouse monoclonal hybridoma antibody is described. The assay is capable of detecting activated factor XII in human plasma and can be used to assess early detection of the intrinsic blood coagulation pathway. No cross reactivity with human factor XII zymogen has been found. The assay was used to assess activation of factor XII in patients with renal failure, pregnancy and diabetes compared to a control group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|