Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation

Autor: Hui Xue, Daniel A. Herzka, Robert J. Lederman, Rajiv Ramasawmy, Peter Kellman, Miguel A. Alcantar, Adrienne E. Campbell-Washburn, Toby Rogers, Delaney R. McGuirt, Anthony Z. Faranesh, Jaffar M. Khan
Rok vydání: 2018
Předmět:
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Coefficient of variation
Sus scrofa
Contrast Media
Blood volume
Heart failure
030204 cardiovascular system & hematology
Hematocrit
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
medicine
Animals
Radiology
Nuclear Medicine and imaging
CMR
Angiology
Carbon Monoxide
Blood Volume
Radiological and Ultrasound Technology
medicine.diagnostic_test
Blood Volume Determination
Ferumoxytol
business.industry
Research
Reproducibility of Results
Magnetic resonance imaging
Repeatability
T1 mapping
medicine.disease
Magnetic Resonance Imaging
Ferrosoferric Oxide
3. Good health
T 1 mapping
lcsh:RC666-701
Models
Animal
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
MRI
Zdroj: Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 20, Iss 1, Pp 1-10 (2018)
ISSN: 1532-429X
Popis: Background The hallmark of heart failure is increased blood volume. Quantitative blood volume measures are not conveniently available and are not tested in heart failure management. We assess ferumoxytol, a marketed parenteral iron supplement having a long intravascular half-life, to measure the blood volume with cardiovascular magnetic resonance (CMR). Methods Swine were administered 0.7 mg/kg ferumoxytol and blood pool T 1 was measured repeatedly for an hour to characterize contrast agent extraction and subsequent effect on V blood estimates. We compared CMR blood volume with a standard carbon monoxide rebreathing method. We then evaluated three abbreviated acquisition protocols for bias and precision. Results Mean plasma volume estimated by ferumoxytol was 61.9 ± 4.3 ml/kg. After adjustment for hematocrit the resultant mean blood volume was 88.1 ± 9.4 ml/kg, which agreed with carbon monoxide measures (91.1 ± 18.9 ml/kg). Repeated measurements yielded a coefficient of variation of 6.9%, and Bland-Altman repeatability coefficient of 14%. The blood volume estimates with abbreviated protocols yielded small biases (mean differences between 0.01–0.06 L) and strong correlations (r 2 between 0.97–0.99) to the reference values indicating clinical feasibility. Conclusions In this swine model, ferumoxytol CMR accurately measures plasma volume, and with correction for hematocrit, blood volume. Abbreviated protocols can be added to diagnostic CMR examination for heart failure within 8 min.
Databáze: OpenAIRE
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