Thermal ablation produced using a surgical toroidal high-intensity focused ultrasound device is independent from hepatic inflow occlusion
| Autor: | M. Rivoire, William Apoutou N'Djin, H. Parmentier, J Favre-Cabrera, David Melodelima, Jean-Yves Chapelon |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Hot Temperature Swine Ultrasonic Therapy medicine.medical_treatment Thermal ablation Focused ultrasound medicine Animals Radiology Nuclear Medicine and imaging Radiological and Ultrasound Technology business.industry Liver Neoplasms Significant difference Ablation High-intensity focused ultrasound Liver Transplantation Oxygen Perfusion Disease Models Animal Liver Regional Blood Flow Catheter Ablation Ultrasound imaging Female Inflow occlusion Radiology business Nuclear medicine |
| Zdroj: | Physics in Medicine and Biology. 54:6353-6368 |
| ISSN: | 1361-6560 0031-9155 |
| DOI: | 10.1088/0031-9155/54/20/021 |
| Popis: | In the liver, the efficacy of radiofrequency or high-intensity focused ultrasound (HIFU) ablation is impaired by blood perfusion. This can be overcome by hepatic inflow occlusion. Here we report the in vivo evaluation of ablations performed in the liver using a surgical toroidal HIFU device used during an open procedure with and without hepatic inflow occlusion. The HIFU device was composed of 256 toroidal-shaped emitters working at 3 MHz and an integrated ultrasound imaging probe working at 7.5 MHz. Using an intermittent Pringle maneuver (IPM), thermal ablations were created in three pigs with hepatic inflow occlusion (IPM group) and in three pigs with normal perfusion (NoIPM group). The ablations were studied on sonograms, macroscopically and microscopically 14 days after the treatment. In the NoIPM group, the average coagulated volume obtained after a 40 s exposure was 7.4 +/- 3.8 cm(3) (2.2-16.6). In the IPM group, the average ablated volume was 6.3 +/- 2.9 cm(3) (2.6-12.1). There was no significant difference between the two groups in terms of ablated volume (p = 0.25), diameter (p = 0.37) or depth (p = 0.61). Therefore, a toroidal-shaped HIFU device allows treatment in the liver that can be considered as independent from hepatic inflow occlusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|