Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans
Autor: | Puja Agarwal, Lisa L. Barnes, Neelum T. Aggarwal, Pankaja Desai, Kristin R. Krueger, Xiaoran Liu, Kumar B. Rajan, Klodian Dhana, Shannon Halloway, Thomas Holland, Denis A. Evans |
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Rok vydání: | 2021 |
Předmět: |
Apolipoprotein E
Epidemiology Apolipoprotein E4 Article Cellular and Molecular Neuroscience Apolipoproteins E Developmental Neuroscience Risk Factors Humans Medicine Cognitive Dysfunction Healthy Lifestyle Cognitive decline Allele Genetic risk business.industry Health Policy Limiting Confidence interval Black or African American Psychiatry and Mental health Lifestyle factors Genetic epidemiology Neurology (clinical) Geriatrics and Gerontology business Demography |
Zdroj: | Alzheimers Dement |
ISSN: | 1552-5279 1552-5260 |
Popis: | Introduction We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans. Methods Using data from the Chicago Health and Aging Project (1993-2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE) e 4 allele and determined a healthy lifestyle using a scoring of five factors: non-smoking, exercising, being cognitively active, having a high-quality diet, and limiting alcohol use. We used linear mixed-effects models to estimate cognitive decline by genetic risk and lifestyle score. Results APOE e 4 allele was associated with faster cognitive decline in both races. However, within APOE e 4 carriers, adherence to a healthy lifestyle (eg., 4 to 5 healthy factors) was associated with a slower cognitive decline by 0.023 (95% confidence interval [CI] 0.004, 0.042) units/year in African Americans and 0.044 (95% CI 0.008, 0.080) units/year in European Americans. Discussion A healthy lifestyle was associated with a slower cognitive decline in African and European Americans. |
Databáze: | OpenAIRE |
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