Cutaneous histopathology of the tick‐bite region in severe fever with thrombocytopenia syndrome
| Autor: | Keiko Kurosawa, Teruo Sakamoto, Naoko Takeo, Tsutomu Daa, Haruto Nishida, Yuriko Sho, Tomoko Yamate, Hiroyuki Matsumoto, Osamu Matsunari, Takaoki Sato, Mizuki Goto, Tadaki Suzuki, Hideki Hasegawa, Shigeo Yokoyama, Yutaka Hatano |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Phlebovirus
medicine.medical_specialty Pathology Biopsy Dermatology Tick Virus 030207 dermatology & venereal diseases 03 medical and health sciences Fatal Outcome 0302 clinical medicine parasitic diseases Humans Medicine Aged Skin Tick Bites biology medicine.diagnostic_test business.industry Syndrome General Medicine Disseminated Intravascular Coagulation biology.organism_classification medicine.disease Thrombocytopenia Severe fever with thrombocytopenia syndrome Phlebotomus Fever 030220 oncology & carcinogenesis Skin biopsy biology.protein RNA Viral Female Histopathology Hemophagocytosis Antibody business |
| Zdroj: | The Journal of Dermatology. 46:409-412 |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/1346-8138.14862 |
| Popis: | A case of severe fever with thrombocytopenia syndrome (SFTS) in which a skin biopsy from the tick-bite region was analyzed is reported. The patient was a 72-year-old woman who developed fever and thrombocytopenia after a tick bite. SFTS was diagnosed from polymerase chain reaction (PCR) analysis of a blood sample. Histopathological analysis of a skin biopsy specimen from the tick-bite region showed CD20-positive perivascular and interstitial immunoblastic cells, which were positive to anti-SFTS virus (SFTSV) nucleoprotein antibody. In addition, SFTSV RNA was detected by real-time PCR from this biopsy specimen. Moreover, hemophagocytosis was also found in the tick-bite region. To the best of our knowledge, this is the first report to analyze the details of the tick-bite region of skin in SFTS, and the first to detect virus-infected cells in the skin. The present findings may help elucidate the mechanisms of entry of SFTSV. |
| Databáze: | OpenAIRE |
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