Spontaneously‐resolving episodes of cytomegalovirus DNAemia in allogeneic hematopoietic stem cell transplant recipients: Virological features and clinical outcomes
| Autor: | David Navarro, Ignacio Torres, José Luis Piñana, Estela Giménez, Alberto Talaya, Eliseo Albert, Ariadna Pérez, Carlos Solano, Juan Carlos Hernández-Boluda |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Remission Spontaneous Congenital cytomegalovirus infection Cytomegalovirus Hematopoietic stem cell transplantation Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Virology Internal medicine medicine Humans Transplantation Homologous In patient 030212 general & internal medicine Aged Retrospective Studies business.industry Hematopoietic Stem Cell Transplantation virus diseases Cmv dnaemia Middle Aged Viral Load medicine.disease Transplant Recipients Conservative strategy Transplantation Infectious Diseases Increased risk Cytomegalovirus Infections DNA Viral Female 030211 gastroenterology & hepatology Allogeneic hematopoietic stem cell transplant business |
| Zdroj: | Journal of Medical Virology. 91:1128-1135 |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.25426 |
| Popis: | It has been reported that low-plasma cytomegalovirus (CMV) DNA loads are associated with an increased risk of overall mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Utilizing a conservative strategy for initiation of preemptive antiviral therapy (>1500 IU/mL), we characterized the virological features of spontaneously-resolving episodes of CMV DNAemia and assessed their impact on mortality through the first year after transplantation. We reviewed the CMV DNA polymerase chain reaction results and clinical charts of 230 consecutive adult patients who underwent T-cell replete allo-HSCT at our center. A total of 280 episodes of CMV DNAemia were registered in 164 patients, of which 144 episodes cleared spontaneously. Clearance of CMV DNAemia was significantly delayed in initial and recurrent self-resolving episodes featuring CMV DNA peak loads > 250 IU/mL compared with those displaying lower values. All-cause mortality in patients with self-resolving episodes of CMV DNAemia was comparable (P = 0.7) to that in patients with no CMV DNAemia and was not related to the CMV DNA peak load (≥250 IU/mL vs |
| Databáze: | OpenAIRE |
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