Sida cordifolia Linn. accelerates wound healing process in type 2 diabetic rats
| Autor: | Fedelic Ashish Toppo, P.K. Lakshmi, Pratibha Suryavanshi, Shweta Anil Kumar, Rajesh Singh Pawar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Incision wound Sida cordifolia wound healing Histopathological examination Critical Care and Intensive Care Medicine excision model 030226 pharmacology & pharmacy Diabetic wound 03 medical and health sciences chemistry.chemical_compound Hydroxyproline 0302 clinical medicine Sida cordifolia Linn incision model Medicine Gallic acid HPLC fingerprinting Traditional medicine biology integumentary system business.industry biology.organism_classification 030104 developmental biology chemistry Emergency Medicine business Wound healing Excision wound |
| Zdroj: | Journal of Acute Medicine. 6(4):82-89 |
| ISSN: | 2211-5587 |
| DOI: | 10.1016/j.jacme.2016.08.004 |
| Popis: | ObjectiveSida cordifolia Linn. (Hindi—kungyi; Sanskrit—bala) is a shrub (family Malvaceae) grown all over India. In Ayurveda, the crushed leaves of the plant is used for the treatment and dressing of wounds. Traditionally, root juice is also used to promote the healing of wounds. This study was designed to evaluate the wound healing potential of hydrogel of methanolic extract of Sida cordifolia Linn. (MeOHSC) in diabetic rats.MethodsThe methanolic extract in the form of hydrogel was applied topically for the management of wounds in fructose-fed streptozotocin-induced diabetic rats. The % wound contraction, period of epithelialization, hydroxyproline content, and histopathological examination were evaluated using the excision wound model, and tensile strength was measured using the incision wound model.ResultsThe results showed that in both models, hydrogel of MeOHSC was found to have significant wound healing activity compared with diabetic wound control in terms of % wound contraction (p |
| Databáze: | OpenAIRE |
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