Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood: Exploring Genetic and Environmental Overlap Across Development
| Autor: | Henrik Larsson, Jan-Olov Larsson, Ralf Kuja-Halkola, Benjamin B. Lahey, Isabell Brikell, Paul Lichtenstein, Jonna Kuntsi, Per-Anders Rydelius |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Adolescent Twins Attention Problems Scale behavioral disciplines and activities Structural equation modeling Developmental psychology 03 medical and health sciences 0302 clinical medicine mental disorders Developmental and Educational Psychology medicine Humans Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences Longitudinal Studies Child Child Behavior Checklist Association (psychology) Sweden 05 social sciences Adolescent Development medicine.disease Twin study Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Etiology Female Gene-Environment Interaction Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Biomedical sciences |
| Zdroj: | Brikell, I, Kuja-Halkola, R, Larsson, J-O, Lahey, B B, Kuntsi, J, Lichtenstein, P, Rydelius, P-A & Larsson, H 2016, ' Relative Immaturity in Childhood and Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Early Adulthood : Exploring Genetic and Environmental Overlap Across Development ', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 55, no. 10, pp. 886-95 . https://doi.org/10.1016/j.jaac.2016.06.014 |
| ISSN: | 0890-8567 |
| DOI: | 10.1016/j.jaac.2016.06.014 |
| Popis: | OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) has been linked to immaturity relative to peers in childhood, yet it is unclear how such immaturity is associated with ADHD across development. This longitudinal twin study examined the genetic and environmental contributions to the association between parents' perception of their child's immaturity relative to peers (RI) in childhood and ADHD symptoms across development.METHOD: 1,302 twin pairs from the Swedish Twin Study of Child and Adolescent Development were followed prospectively from childhood to early adulthood. Parent ratings of RI were collected at 8 to 9 years and parent and self-ratings of ADHD symptoms were collected at 8 to 9, 13 to 14, 16 to 17, and 19 to 20 years using the Child Behavior Checklist Attention Problems scale. In addition, ADHD symptoms corresponding to DSM criteria were used for sensitivity analysis. Analyses were conducted using longitudinal structural equation modeling with multiple raters.RESULTS: RI-related etiologic factors, predominantly influenced by genes, explained 10-14% of the variance in ADHD symptoms from 8 to 9 up to 16 to 17 years. The influence of these RI-related factors on ADHD symptoms attenuated to 4% by 19 to 20 years of age. The remaining variance in ADHD symptoms was primarily explained by genetic factors independent of RI, which remained relatively stable across development, explaining 19% to 30% of the variance in ADHD symptoms from 13 to 14 up to 19 to 20 years.CONCLUSION: The results show that RI is significantly associated with ADHD symptoms, particularly during childhood and adolescence, and that the association is primarily explained by a shared genetic liability. Nevertheless, the magnitude of associations across development was modest, highlighting that RI is merely one aspect contributing to the complex etiology of ADHD symptoms. |
| Databáze: | OpenAIRE |
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