Propionic Acid Produced by Propionibacterium acnes Strains Contri-butes to Their Pathogenicity
| Autor: | Kornélia Szabó, Tamás Bíró, Róbert Puskás, Lajos Kemény, Gábor Tax, Edit Urbán, Zsuzsanna Palotás, Zoltán Kónya |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Keratinocytes Time Factors Dermatology Bacterial growth Microbiology Cell Line 030207 dermatology & venereal diseases 03 medical and health sciences Propionibacterium acnes 0302 clinical medicine Humans Microbiome Elméleti orvostudományok Cytotoxicity Cell Proliferation biology Cell growth General Medicine Orvostudományok Hydrogen-Ion Concentration biology.organism_classification Antimicrobial Bacterial Load 030104 developmental biology Biochemistry Cell culture Host-Pathogen Interactions Propionates Bacteria |
| Zdroj: | Acta dermato-venereologica. 96(1) |
| ISSN: | 1651-2057 |
| Popis: | Propionibacterium acnes is an important member of the skin microbiome. The bacterium can initiate signalling events and changes in cellular properties in keratinocytes. The aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. The results show that various P. acnes strains affect the cell-growth properties of these cells differentially, inducing cytotoxicity in a strain-specific and dose-dependent manner. We propose that bacterially secreted propionic acid may contribute to the cytotoxic effect. This acid has a role in maintaining skin pH and exhibits antimicrobial properties, but may also have deleterious effects when the local concentration rises due to excessive bacterial growth and metabolism. These results, together with available data from the literature, may provide insight into the dual role of P. acnes in healthy skin and during pathogenic conditions, as well as the key molecules involved in these functions. |
| Databáze: | OpenAIRE |
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