Defective interfering particles of parvovirus H-1
| Autor: | S L Rhode rd |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
DNA Replication
Genes Viral Ultraviolet Rays Parvovirus H-1 viruses Immunology Virus Replication Microbiology Parvoviridae Defective virus Virus Cell Line Capsid Virology Viral Interference biology Parvovirus Defective Viruses biology.organism_classification Molecular biology Viral replication Defective interfering particle Insect Science DNA Viral Research Article |
| Zdroj: | Journal of Virology. 27:347-356 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Defective interfering particles of the parvovirus H-1 were produced by serial propagation at high multiplicities of infection. Such particles interfere with the synthesis of capsid proteins and infectious virus of standard H-1. The interference is sensitive to UV irradiation, dependent on the multiplicity of the challenge virus, and is active in heterotypic infections against parvovirus H-3 or LuIII. Defective interfering particle genomes have alterations characterized by integral numbers (1 to 10 or more) of a 60-base-pair addition in the neighborhood of the origin of replicative-form DNA replication and deletions that are located primarily within two regions, 32 to 44 or 80 to 90 on the genome map. Some of the implications of these findings are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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