Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain
| Autor: | Robert J. Christy, Thomas H. Garza, Winfred Stacey, Bopaiah P. Cheppudira, N. Sosanya, Stephen L. Crimmins |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty p-TrkB Chronic intermittent stress Hypothalamus Pain Prefrontal Cortex Tropomyosin receptor kinase B Cyclotraxin-B Peptides Cyclic lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Mechanical allodynia Stress Physiological Internal medicine medicine Animals Receptor trkB Phosphorylation Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Brain-derived neurotrophic factor Thermal injury business.industry General Neuroscience Brain-Derived Neurotrophic Factor lcsh:QP351-495 TrkB Rats Nerve growth factor Endocrinology Nociception BDNF lcsh:Neurophysiology and neuropsychology nervous system Hyperalgesia business Burns 030217 neurology & neurosurgery Research Article |
| Zdroj: | BMC Neuroscience, Vol 20, Iss 1, Pp 1-18 (2019) BMC Neuroscience |
| ISSN: | 1471-2202 |
| DOI: | 10.1186/s12868-019-0500-1 |
| Popis: | Background Reports show that stressful events before injury exacerbates post-injury pain. The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we examined the effects of chronic intermittent stress (CIS) on nociceptive behaviors and brain-derived nerve growth factor (BDNF) system in the prefrontal cortex (PFC) and hypothalamus of rats with and without thermal injury. Results Unstressed rats showed transient mechanical allodynia during stress exposure. Stressed rats with thermal injury displayed persistent exacerbated mechanical allodynia (P |
| Databáze: | OpenAIRE |
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