Evidence of Borrelia Autoimmunity-Induced Component of Lyme Carditis and Arthritis
| Autor: | Steven E. Schutzer, Helen Bateman, Madeleine W. Cunningham, Brian A. McCarthy, Helen Fernandes, Elizabeth Raveche, Steven P. Nickell |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Lipoproteins Spirochaetaceae Cross Reactions medicine.disease_cause Microbiology Autoimmunity Autoimmune Diseases Mice Lyme disease Borrelia medicine Animals Humans Borrelia burgdorferi Arthritis Infectious Lyme Disease Mice Inbred BALB C biology Mice Inbred NZB Carditis Bacteriology medicine.disease biology.organism_classification bacterial infections and mycoses Virology Antibodies Bacterial Bacterial vaccine Molecular mimicry Myocarditis Immunoglobulin M Mice Inbred DBA Antigens Surface Bacterial Vaccines bacteria Bacterial Outer Membrane Proteins |
| Popis: | We investigated the possibility that manifestations of Lyme disease in certain hosts, such as arthritis and carditis, may be autoimmunity mediated due to molecular mimicry between the bacteriumBorrelia burgdorferiand self-components. We first compared amino acid sequences ofStreptococcus pyogenesM protein, a known inducer of antibodies that are cross-reactive with myosin, andB. burgdorferiand found significant homologies with OspA protein. We found thatS. pyogenesM5-specific antibodies and sera fromB. burgdorferi-infected mice reacted with both myosin andB. burgdorferiproteins by Western blots and enzyme-linked immunosorbent assay. To investigate the relationship between self-reactivity and the response toB. burgdorferi, NZB mice, models of autoimmunity, were infected. NZB mice infected withB. burgdorferideveloped higher degrees of joint swelling and higher anti-B. burgdorferiimmunoglobulin M cross-reactive responses than other strains with identical major histocompatibility complex (DBA/2 and BALB/c). These studies reveal immunological cross-reactivity and suggest thatB. burgdorferimay share common epitopes which mimic self-proteins. These implications could be important for certain autoimmunity-susceptible individuals or animals who become infected withB. burgdorferi. |
| Databáze: | OpenAIRE |
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