Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes – AGES-Reykjavik Study
| Autor: | Tamara B. Harris, Vilmundur Gudnason, Cindy Mari Imai, Laufey Steingrimsdottir, Lenore J. Launer, Inga Thorsdottir, Ingibjorg Gunnarsdottir, Thorhallur I. Halldorsson, Mary Frances Cotch, Gudny Eiriksdottir |
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| Rok vydání: | 2015 |
| Předmět: |
Gerontology
medicine.medical_specialty Chemiluminescence immunoassay Endocrinology Diabetes and Metabolism 25(OH)D 25-hydroxyvitamin D Internal medicine medicine Vitamin D and neurology Vitamin D Serum 25 hydroxyvitamin d Depression (differential diagnoses) Mini-international neuropsychiatric interview Nutrition and Dietetics Nutritional epidemiology Depression business.industry GDS Geriatric Depression Scale MINI Mini-International Neuropsychiatric Interview medicine.disease 3. Good health Older adults Major depressive disorder Geriatric Depression Scale business Cross-sectional analyses AGES-Reykjavik Age Gene/Environment Susceptibility–Reykjavik Research Article Food Science |
| Zdroj: | Journal of Nutritional Science |
| ISSN: | 2048-6790 |
| DOI: | 10.1017/jns.2015.27 |
| Popis: | Low vitamin D status may be associated with depression. Few studies have examined vitamin D and depression in older adults living at northern latitudes. The present study cross-sectionally investigated serum 25-hydroxyvitamin D (25(OH)D) status and depression among 5006 community-dwelling older persons (66–96 years) living in Iceland (latitudes 64–66°N). Depressive symptoms were measured by the fifteen-item Geriatric Depression Scale (GDS-15). Current major depressive disorder was assessed according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Serum 25(OH)D was analysed using chemiluminescence immunoassay and categorised into three groups: deficient (v.adequate vitamin D status had more depressive symptoms (higher GDS-15 scores) (difference 0·7 (95 % CI 0·4, 0·9) and 0·4 (95 % CI 0·1, 0·6), respectively). Furthermore, men with deficient vitamin D status were more likely to have current major depressive disorder (adjusted OR 2·51; 95 % CI 1·03, 6·13) compared with men with adequate vitamin D status. Associations among women were not significant. In this older population living at northern latitudes, deficient vitamin D status may be associated with depression. Further investigations are warranted to evaluate the pathways that may be associated with risk of depression among older adults. |
| Databáze: | OpenAIRE |
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