Evaluation of rat and rabbit sera lipoproteins in experimentally induced hyperlipidemia by analytical ultracentrifugation

Autor: Z. Bozóky, Domokos Máthé, Lajos Balogh, L. Fülöp, Gy. A. Jánoki
Rok vydání: 2005
Předmět:
Zdroj: European Biophysics Journal. 35:205-213
ISSN: 1432-1017
0175-7571
DOI: 10.1007/s00249-005-0022-x
Popis: Animals of various species are widely used as models with which to study atherosclerosis and the lipoprotein metabolism. The objective of this study was to investigate the lipoprotein profiles in Wistar rats and New Zealand white rabbits with experimentally induced hyperlipidemia by means of ultracentrifugation. The Schlieren curves were utilized to compare suckling and adult rat sera to determine whether aging causes alterations in lipoprotein profiles. A striking feature of the data is the high concentration of low-density lipoproteins (LDL), (>5.2 mmol/l cholesterol) in the 2-week old rat serum pool which was greatly decreased in the 3-weeks rat serum pool (
Databáze: OpenAIRE