Evaluation of rat and rabbit sera lipoproteins in experimentally induced hyperlipidemia by analytical ultracentrifugation
Autor: | Z. Bozóky, Domokos Máthé, Lajos Balogh, L. Fülöp, Gy. A. Jánoki |
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Rok vydání: | 2005 |
Předmět: |
Very low-density lipoprotein
medicine.medical_specialty Cholesterol VLDL Hypercholesterolemia Biophysics Blood lipids Polyethylene Glycols Cholesterol Dietary Analytical Ultracentrifugation chemistry.chemical_compound Species Specificity In vivo medicine.artery Internal medicine Hyperlipidemia Centrifugation Density Gradient medicine Animals Rats Wistar Radionuclide Imaging Radioisotopes Aorta Cholesterol Microscopy Ultraviolet Cholesterol HDL Age Factors Technetium Cholesterol LDL General Medicine medicine.disease Rats Disease Models Animal Refractometry Endocrinology chemistry lipids (amino acids peptides and proteins) Rabbits Lipoprotein |
Zdroj: | European Biophysics Journal. 35:205-213 |
ISSN: | 1432-1017 0175-7571 |
DOI: | 10.1007/s00249-005-0022-x |
Popis: | Animals of various species are widely used as models with which to study atherosclerosis and the lipoprotein metabolism. The objective of this study was to investigate the lipoprotein profiles in Wistar rats and New Zealand white rabbits with experimentally induced hyperlipidemia by means of ultracentrifugation. The Schlieren curves were utilized to compare suckling and adult rat sera to determine whether aging causes alterations in lipoprotein profiles. A striking feature of the data is the high concentration of low-density lipoproteins (LDL), (>5.2 mmol/l cholesterol) in the 2-week old rat serum pool which was greatly decreased in the 3-weeks rat serum pool ( |
Databáze: | OpenAIRE |
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