Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation
Autor: | Akhgar Ghassabian, Mady Hornig, Jill M. Goldstein, Stephen L. Buka, Stephen E. Gilman, Jing Yu, Zhen Chen, Risë B. Goldstein |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Mediation (statistics) Offspring Immunology Context (language use) Article Self-Control 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Immune system Child Development Pregnancy Medicine Humans Child Socioeconomic status Endocrine and Autonomic Systems business.industry Tumor Necrosis Factor-alpha Mental Disorders medicine.disease Child development 030104 developmental biology Child Preschool Prenatal Exposure Delayed Effects Cytokines Racial differences Female business 030217 neurology & neurosurgery Demography |
Zdroj: | Brain Behav Immun |
ISSN: | 1090-2139 |
Popis: | Maternal immune activity during pregnancy has been associated with risk for psychiatric disorders in offspring, but less is known about its implications for children’s emotional and behavioral development. This study examined whether concentrations of five cytokines assayed from prenatal serum were associated with socioeconomic status (SES) and racial disparities in their offspring’s self-regulation abilities. Participants included 1628 women in the Collaborative Perinatal Project (CPP). Seven behavioral items conceptually related to self-regulation were rated by CPP psychologists when children were 4 years old. Concentrations of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and IL-10 were assessed. Covariates included child sex and mother’s age, psychiatric disorders, and medical conditions during pregnancy. There were significant SES differences in child self-regulation, with higher SES children scoring higher on self-regulation (β = 0.18, 95% CI [0.11, 0.25]), but no racial differences. The concentration of IL-8 in maternal serum was associated with higher child self-regulation, β = 0.09, 95% CI [0.02, 0.16]. In mediation analyses, variation in maternal IL-8 contributed to the association between family SES and child self-regulation (β = 0.02, 95% CI [0.003, 0.030]), explaining about one-tenth of the SES disparities. This study suggests pregnancy as an early sensitive period and maternal immune activity as an important context for child development. |
Databáze: | OpenAIRE |
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