Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
| Autor: | Elen Almeida Romão, Anderson Marliere Navarro, Rodrigo de Carvalho Santana, Mariana Palma Guimarães, Renata Dessordi, Ana de Lourdes Candolo Martinelli, Lígia Moriguchi Watanabe |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Deoxypyridinoline Osteoclasts Parathyroid hormone Bone tissue chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine Bone Density Bone mineral Lumbar Vertebrae Multidisciplinary biology Femur Neck Middle Aged Hepatitis B medicine.anatomical_structure Anti-Retroviral Agents Lamivudine Body Composition Osteocalcin Medicine Female 030211 gastroenterology & hepatology Adult Hepatitis B virus medicine.medical_specialty Guanine Science Bone resorption 03 medical and health sciences Hepatitis B Chronic Internal medicine medicine Humans Bone Resorption Tenofovir Hip business.industry medicine.disease Osteopenia Fibroblast Growth Factor-23 Cross-Sectional Studies 030104 developmental biology Endocrinology chemistry biology.protein business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| Popis: | Made available in DSpace on 2021-06-25T11:00:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Nucleoside/nucleotide analogs such as tenofovir, have been used as long-term therapy for the treatment of hepatitis B and side effects such as the reduction in bone mineral density have been associated with their use. To determine the relationships between bone, hormonal, biochemical, and mineral parameters in patients with hepatitis B treated with nucleoside/nucleotide antiviral. A cross-sectional study was conducted with 81 adult patients with chronic hepatitis B infection. Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density. Biochemical analyses were performed for osteocalcin, deoxypyridinoline, parathyroid hormone, vitamin D, IGF-1, TSH, testosterone, estradiol, FSH, transaminases, urea, creatinine, calcium, serum and urinary phosphorus, magnesium, and FGF-23, body composition was performed by DXA. Participants, both gender, were divided according to the use of antiretrovirals: Group1: 27 inactive virus carriers without medication; Group2: 27 patients using tenofovir; and Group3: 27 patients using lamivudine or entecavir. DXA readings diagnosed osteopenia in the lumbar spine for 7.4% of individuals in Group1, 15% in Group2, and 3.7% in Group3. For all groups, we observed normal values in bone formation markers, osteocalcin levels as well as parathyroid hormone, insulin growth factor 1, and FGF-23. In all groups, we found increased levels of urinary deoxypyridinoline, a bone resorption marker. Increased levels in the bone resorption markers indicated a high resorptive activity of bone tissue. These data suggested high resorption activity of bone tissue in hepatitis B virus-infected patients independent of the use of antiretrovirals. Department of Food and Nutrition Faculty of Pharmaceutical Sciences State University of São Paulo – UNESP, Endereço: Avenida Bandeirantes, 3900. Monte Alegre Department of Clinical Medicine Ribeirão Preto Medical School University of São Paulo - FMRP/USP Department of Food and Nutrition Faculty of Pharmaceutical Sciences State University of São Paulo – UNESP, Endereço: Avenida Bandeirantes, 3900. Monte Alegre |
| Databáze: | OpenAIRE |
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