Influences of Selenium-Enriched Yeast on Growth Performance, Immune Function, and Antioxidant Capacity in Weaned Pigs Exposure to Oxidative Stress

Autor: Bing Yu, Hui Yan, Daiwen Chen, Lei Liu, Zhiqing Huang, Ping Zheng, Yuheng Luo, Xiangbing Mao, Junqiu Luo, Jie Yu, Jun He
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Antioxidant
Swine
medicine.medical_treatment
medicine.disease_cause
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
chemistry.chemical_classification
biology
Glutathione peroxidase
Alanine Transaminase
General Medicine
Liver
Catalase
Medicine
Cytokines
Digestion
030211 gastroenterology & hepatology
Research Article
medicine.medical_specialty
Article Subject
Saccharomyces cerevisiae
Thymus Gland
Weaning
Diquat
General Biochemistry
Genetics and Molecular Biology
Transaminase
Superoxide dismutase
Selenium
03 medical and health sciences
Internal medicine
medicine
Animals
Aspartate Aminotransferases
Inflammation
General Immunology and Microbiology
Nutrients
Oxidative Stress
Viscera
030104 developmental biology
Endocrinology
Gene Expression Regulation
chemistry
Immunoglobulin G
biology.protein
Oxidative stress
Zdroj: BioMed Research International
BioMed Research International, Vol 2021 (2021)
ISSN: 2314-6133
DOI: 10.1155/2021/5533210
Popis: This study elucidated the function role of dietary selenium-enriched yeast (SeY) supplementation on growth performance, immune function, and antioxidant capacity in weaned pigs exposure to oxidative stress. Thirty-two similarity weight pigs were randomly divided into four treatments: (1) nonchallenged control, (2) control+SeY, (3) control+diquat, and (4) control+SeY+diquat. The period of experiment was 21 days; on day 16, pigs were injected with diquat or sterile saline. Results revealed that oxidative stress was notably detrimental to the growth performance of piglets, but SeY supplementation ameliorated this phenomenon, which might be regarding the increasing of body antioxidant capacity and immune functions. In details, SeY supplementation improved the digestibility of crude protein (CP), ash, and gross energy (GE). Moreover, the serum concentrations of proinflammatory cytokines (TNF-α, IL-1β, and IL-6), glutamic-pyruvic transaminase(GPT), and glutamic-oxaloacetic transaminase (GOT) were reduced via SeY supplemented, and serum concentrations of immunoglobulins A (IgA), IgG, and activities of antioxidant enzymes such as the superoxide dismutase (SOD), catalase (CAT) ,and glutathione peroxidase (GSH-Px) were improved in the diquat-challenged pigs ( P < 0.05 ). In addition, SeY supplementation acutely enhanced the activities of these antioxidant enzymes in the liver and thymus upon diquat challenge, which involved with the upregulation of the critical genes related antioxidant signaling such as the nuclear factor erythroid-derived 2-related factor 2 (Nrf-2) and heme oxygenase-1 (HO-1) ( P < 0.05 ). Importantly, we also found that SeY supplementation apparently reduced the malondialdehyde (MDA) concentrations in the liver, thymus, and serum ( P < 0.05 ). Specifically, the expression levels of TNF-α, IL-6, IL-1β, Toll-like receptor 4 (TLR-4), and nuclear factor-κB (NF-κB) in the liver and thymus were downregulated by SeY upon diquat challenge. These results suggested that SeY can attenuate oxidative stress-induced growth retardation, which was associated with elevating body antioxidant capacity, immune functions, and suppressed inflammatory response.
Databáze: OpenAIRE
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