Antimicrobial activity of fusidic acid inclusion complexes
Autor: | Narcis Duteanu, Laura Vicas, Bogdan Tita, L. Antal, Otilia Tica, Otilia Micle, Annamaria Pallag, Eleonora Marian, Tunde Jurca, Stefania Ciocan, Mariana Muresan |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Microbiology (medical) Methicillin-Resistant Staphylococcus aureus Staphylococcus aureus Fusidic acid 030106 microbiology Antimicrobial activity medicine.disease_cause lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine X-Ray Diffraction Spectroscopy Fourier Transform Infrared medicine Cyclodextrin Humans lcsh:RC109-216 030212 general & internal medicine Cefoxitin Fourier transform infrared spectroscopy Thermal analysis chemistry.chemical_classification Chemistry Compounds characterization beta-Cyclodextrins General Medicine Antimicrobial Anti-Bacterial Agents Infectious Diseases Freeze Drying Microscopy Electron Scanning Staphylococcus Fusidic Acid medicine.drug Nuclear chemistry |
Zdroj: | International Journal of Infectious Diseases, Vol 101, Iss, Pp 65-73 (2020) |
ISSN: | 1878-3511 |
Popis: | Objectives To synthesize and characterize the inclusion complexes of fusidic acid with β – cyclodextrin, followed by the evaluation of their antimicrobial activity against pure strain (Staphylococcus aureus ATCC 25,923) and isolated Staphylococcus from clinical cases. Methods The desired compounds were synthesized using molar ratio of fusidic acid: β-cyclodextrin of 1:1. Synthesized compounds were analyzed by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Thermal Analysis, and the results confirmed the formation of inclusion compounds by fusidic acid with β-cyclodextrin. Results Physical–chemical characterization confirmed the preparation of desired inclusion compounds, and the antimicrobial test confirmed that all compounds obtained have antimicrobial activity. Antimicrobial activity of freeze-drying complex againstS. aureus is similar with pure fusidic acid activity, being better than the cefoxitin one. Similar behavior was observed against methicillin-resistant S. aureus and S. epidermidis. Conclusions In the present work, three different inclusion complexes of fusidic acid were prepared using three different preparation methods. All inclusion complexes obtained presented good antimicrobial activity against differentS. aureus strains. Antimicrobial activity of these new prepared compounds was observed to be better than that of cefoxitin. |
Databáze: | OpenAIRE |
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