Time Course Effect of Thyroxine on Serum Lipoprotein Concentrations in Hypothyroid Subjects
| Autor: | U Rosenqvist, B Hylander |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein Time Factors Lipoproteins Thyrotropin Dose level chemistry.chemical_compound Hypothyroidism Internal medicine Internal Medicine medicine Humans Triglycerides Aged Ldl cholesterol Cholesterol business.industry Plasma levels Middle Aged Increased LDL cholesterol Thyroxine Endocrinology chemistry Time course Female lipids (amino acids peptides and proteins) business Lipoprotein |
| Zdroj: | Acta Medica Scandinavica. 211:287-291 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1982.tb01946.x |
| Popis: | In order to analyse the time course effect of thyroxine replacement therapy on lipoprotein concentrations, 12 hypothyroid subjects were studied before and repeatedly during therapy. The substitution dose was increased gradually every fourth week until the plasma level of TSH became normal. The concentrations of cholesterol and triglycerides were analysed in whole serum and in the three major lipoprotein fractions VLDL, LDL and HDL. The main abnormality before treatment was an increased LDL cholesterol concentration. Normalization of serum LDL was established at a dose level which normalized TSH. The onset of the effect of thyroxine on LDL cholesterol was rapid and could be noted already after two weeks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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