Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation
Autor: | Giovanna Ogge, Lami Yeo, Roberto Romero, Laura Cruciani, Sun Kwon Kim, Edi Vaisbuch, Tinnakorn Chaiworapongsa, Percy Pacora, Francesca Gotsch, Juan Pedro Kusanovic, Zhong Dong, Offer Erez, Pooja Mittal, Sonia S. Hassan, Ronald F. Lamont, Gian Carlo Di Renzo, Shali Mazaki-Tovi |
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Rok vydání: | 2010 |
Předmět: |
Adult
medicine.medical_specialty Amniotic fluid Chorioamnionitis Gastroenterology Statistics Nonparametric Article Young Adult Obstetric Labor Premature Pregnancy Internal medicine medicine Preterm delivery Birth Weight Humans Rupture of membranes Amnion Preterm labor (PTL) Preterm prelabor rupture of membranes (PROM) Pregnancy Complications Infectious Amniocentesis Cytokines Microbial invasion of the amniotic cavity (MIAC) Pattern recognition receptors (PRRs) Fetus biology medicine.diagnostic_test Obstetrics business.industry C-reactive protein Infant Newborn Obstetrics and Gynecology Gestational age Amniotic Fluid medicine.disease female genital diseases and pregnancy complications Serum Amyloid P-Component C-Reactive Protein Cross-Sectional Studies medicine.anatomical_structure embryonic structures Pediatrics Perinatology and Child Health biology.protein Female business |
Zdroj: | Journal of Perinatal Medicine. 38 |
ISSN: | 1619-3997 0300-5577 |
DOI: | 10.1515/jpm.2009.141 |
Popis: | Objective: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR) that has an important role in immunoregulation and vascular integrity. The aim of this study was to determine if PTX3 is present in amniotic fluid (AF) and whether its concentration changes with gestational age (GA), in the presence of preterm or term labor, and in cases of intra-amniotic infection/inflammation (IAI) associated with spontaneous preterm labor (PTL) or preterm prelabor rupture of membranes (PROM). Study design: This cross-sectional study included the following groups: 1) mid-trimester (n=45) ; 2) uncomplicated pregnancies at term with (n=48) and without (n=40) spontaneous labor; 3) women with PTL and intact membranes who: a) delivered at term (n = 44); b) delivered preterm without IAI (n=40); or c) delivered preterm with IAI (n=62); 4) women with preterm PROM with (n=63) and without (n = 36) IAI. PTX3 concentration in AF was determined by ELISA. Non-parametric statistics were used for analyses. Results: 1) Among women with PTL and intact membranes, the median AF PTX3 concentration was significantly higher in women with IAI than in those without IAI (7.95 ng/mL vs. 0.38 ng/mL; P |
Databáze: | OpenAIRE |
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