Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation

Autor: Giovanna Ogge, Lami Yeo, Roberto Romero, Laura Cruciani, Sun Kwon Kim, Edi Vaisbuch, Tinnakorn Chaiworapongsa, Percy Pacora, Francesca Gotsch, Juan Pedro Kusanovic, Zhong Dong, Offer Erez, Pooja Mittal, Sonia S. Hassan, Ronald F. Lamont, Gian Carlo Di Renzo, Shali Mazaki-Tovi
Rok vydání: 2010
Předmět:
Adult
medicine.medical_specialty
Amniotic fluid
Chorioamnionitis
Gastroenterology
Statistics
Nonparametric

Article
Young Adult
Obstetric Labor
Premature

Pregnancy
Internal medicine
medicine
Preterm delivery
Birth Weight
Humans
Rupture of membranes
Amnion
Preterm labor (PTL)
Preterm prelabor rupture of membranes (PROM)
Pregnancy Complications
Infectious

Amniocentesis
Cytokines
Microbial invasion of the amniotic cavity (MIAC)
Pattern recognition receptors (PRRs)
Fetus
biology
medicine.diagnostic_test
Obstetrics
business.industry
C-reactive protein
Infant
Newborn

Obstetrics and Gynecology
Gestational age
Amniotic Fluid
medicine.disease
female genital diseases and pregnancy complications
Serum Amyloid P-Component
C-Reactive Protein
Cross-Sectional Studies
medicine.anatomical_structure
embryonic structures
Pediatrics
Perinatology and Child Health

biology.protein
Female
business
Zdroj: Journal of Perinatal Medicine. 38
ISSN: 1619-3997
0300-5577
DOI: 10.1515/jpm.2009.141
Popis: Objective: Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR) that has an important role in immunoregulation and vascular integrity. The aim of this study was to determine if PTX3 is present in amniotic fluid (AF) and whether its concentration changes with gestational age (GA), in the presence of preterm or term labor, and in cases of intra-amniotic infection/inflammation (IAI) associated with spontaneous preterm labor (PTL) or preterm prelabor rupture of membranes (PROM). Study design: This cross-sectional study included the following groups: 1) mid-trimester (n=45) ; 2) uncomplicated pregnancies at term with (n=48) and without (n=40) spontaneous labor; 3) women with PTL and intact membranes who: a) delivered at term (n = 44); b) delivered preterm without IAI (n=40); or c) delivered preterm with IAI (n=62); 4) women with preterm PROM with (n=63) and without (n = 36) IAI. PTX3 concentration in AF was determined by ELISA. Non-parametric statistics were used for analyses. Results: 1) Among women with PTL and intact membranes, the median AF PTX3 concentration was significantly higher in women with IAI than in those without IAI (7.95 ng/mL vs. 0.38 ng/mL; P
Databáze: OpenAIRE