Exosomes as Drug Carriers for Cancer Therapy
| Autor: | Jiha Kim, Sanku Mallik, Jessica E Pullan, Kausik Sarkar, Jenna Osborn, Matthew Confeld |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Biocompatibility
Cancer therapy Pharmaceutical Science 02 engineering and technology Exosomes 030226 pharmacology & pharmacy 03 medical and health sciences Mice 0302 clinical medicine Drug Delivery Systems Prostate Neoplasms Drug Discovery medicine Animals Humans Solid tumor Zebrafish Biological Products Drug Carriers business.industry 021001 nanoscience & nanotechnology Xenograft Model Antitumor Assays Microvesicles medicine.anatomical_structure Milk Targeted drug delivery Drug delivery Cancer research Molecular Medicine Nanoparticles 0210 nano-technology business Drug carrier |
| Zdroj: | Molecular pharmaceutics. 16(5) |
| ISSN: | 1543-8392 |
| Popis: | Exosomes, biological extracellular vesicles, have recently begun to find use in targeted drug delivery in solid tumor research. Ranging from 30-120 nm in size, exosomes are secreted from cells and isolated from bodily fluids. Exosomes provide a unique material platform due to their characteristics, including physical properties such as stability, biocompatibility, permeability, low toxicity, and low immunogenicity-all critical to the success of any nanoparticle drug delivery system. In addition to traditional chemotherapeutics, natural products and RNA have been encapsulated for the treatment of breast, pancreatic, lung, prostate cancers, and glioblastoma. This review discusses current research on exosomes for drug delivery to solid tumors. |
| Databáze: | OpenAIRE |
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