Lupus nephritis associated with nephrotic syndrome
| Autor: | Yoshie Sasatomi, Hitoshi Nakashima, Katsuhisa Miyake |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Nephrotic Syndrome business.industry Immunology Lupus nephritis General Medicine Immune complex formation medicine.disease Lupus Nephritis immune system diseases medicine Animals Humans Immunology and Allergy Diffuse Lupus Nephritis Histopathology skin and connective tissue diseases business Nephrotic syndrome Pathological Nephritis Anti-SSA/Ro autoantibodies |
| Zdroj: | Japanese Journal of Clinical Immunology. 36:129-133 |
| ISSN: | 1349-7413 0911-4300 |
| DOI: | 10.2177/jsci.36.129 |
| Popis: | Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease that is characterized by the production of multiple autoantibodies and immune complex formation. Lupus nephritis (LN), which has various histological patterns and variable clinical outcomes, is one of the most important complications of SLE. Although this pathogenetic mechanism in each histologically different type of nephritis remains unclear, recent findings in LN elucidate an essential role for the Th1, IL-17 producing T cells and Th17 cells in the development of diffuse lupus nephritis (DLN), and Th2 cytokine in that of membranous lupus nephritis (MLN). These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of LN. Therefore the suppression of pivotal role cytokines in each pathological condition may support immunosuppressant strategy for LN. |
| Databáze: | OpenAIRE |
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