Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers
| Autor: | Nicolas Wernert, Micaela Mathiak, Alexandra Florin, Simona Kirdorf, Elisabeth Mangold, Peter Behrens, Axel Wellmann, Marcus Rothe, Franz Fogt |
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| Rok vydání: | 2003 |
| Předmět: |
Adenoma
Adult Cancer Research Pathology medicine.medical_specialty Stromal cell Biology Matrix metalloproteinase Gene Expression Regulation Enzymologic Extracellular matrix Immunoenzyme Techniques Proto-Oncogene Protein c-ets-1 Stroma Proto-Oncogene Proteins medicine Carcinoma Humans Neoplasm Invasiveness RNA Messenger In Situ Hybridization Aged Aged 80 and over Proto-Oncogene Proteins c-ets Cell Differentiation Fibroblasts Middle Aged medicine.disease Phenotype Colorectal Neoplasms Hereditary Nonpolyposis Extracellular Matrix Gene Expression Regulation Neoplastic Oncology Matrix Metalloproteinase 9 Immunohistochemistry Matrix Metalloproteinase 1 Stromal Cells Colorectal Neoplasms Transcription Factors |
| Zdroj: | International journal of cancer. 107(2) |
| ISSN: | 0020-7136 |
| Popis: | Hereditary nonpolyposis colorectal cancers (HNPCCs) are an important subgroup of colorectal carcinomas. Compared to sporadic variants, they present several particular features, the most important of which are less invasive and metastatic properties linked to a more favorable prognosis. This contrasts to the generally poor differentiation of the epithelial tumor component. Since matrix-degrading proteases secreted by stromal fibroblasts contribute significantly to tumor invasion, we analyzed the stromal expression of 2 matrix metalloproteinases (MMP-1 and -9) and of one of their regulators, the Ets 1 transcription factor, by both immunohistochemistry and in situ hybridization in sporadic colorectal carcinomas and HNPCC tumors. We found that MMP-1 and -9 as well as Ets 1 are upregulated in the fibroblastic stroma during the development from sporadic adenomas to invasive carcinomas. HNPCC tumors exhibited a significantly lower expression of Ets 1, MMP-1 and -9. These findings on the basis of lower matrix-degrading properties of the fibroblastic tumor stroma in HNPCC tumors might help to explain why, in spite of their less differentiated phenotype, HNPCC tumors have a less invasive and metastatic potential compared to sporadic cancers. |
| Databáze: | OpenAIRE |
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