OrthoNets: simultaneous visual analysis of orthologs and their interaction neighborhoods across different organisms
| Autor: | James Vlasblom, Andrei L. Turinsky, Shoshana J. Wodak, Jack Greenblatt, Brian Turner, Shuye Pu, Denitza Roudeva, Anna Merkoulovitch, Yanqi Hao |
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| Rok vydání: | 2011 |
| Předmět: |
Statistics and Probability
Biology computer.software_genre Biochemistry User-Computer Interface 03 medical and health sciences 0302 clinical medicine Protein Interaction Mapping Databases Protein Molecular Biology Organism 030304 developmental biology 0303 health sciences Systems Biology Computational Biology Proteins Computer Science Applications Applications Note Computational Mathematics Computational Theory and Mathematics 030220 oncology & carcinogenesis Protein Interaction Networks Identification (biology) Data mining computer Software Large size |
| Zdroj: | Bioinformatics |
| ISSN: | 1367-4811 1367-4803 |
| DOI: | 10.1093/bioinformatics/btr035 |
| Popis: | Motivation: Protein interaction networks contain a wealth of biological information, but their large size often hinders cross-organism comparisons. We present OrthoNets, a Cytoscape plugin that displays protein–protein interaction (PPI) networks from two organisms simultaneously, highlighting orthology relationships and aggregating several types of biomedical annotations. OrthoNets also allows PPI networks derived from experiments to be overlaid on networks extracted from public databases, supporting the identification and verification of new interactors. Any newly identified PPIs can be validated by checking whether their orthologs interact in another organism. Availability: OrthoNets is freely available at http://wodaklab.org/orthonets/. Contact: jim.vlasblom@utoronto.ca |
| Databáze: | OpenAIRE |
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