Prospective association between dietary pesticide exposure profiles and Type 2 Diabetes risk

Autor:	P Rebouillat, R Vidal, B Taupier-Letage, L Debrauwer, L Gamet-Payrastre, M Touvier, LK Fézeu, D Lairon, J Baudry, E Kesse-Guyot
Přispěvatelé:	Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Technique de l'Agriculture Biologique (ITAB), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153))
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	[SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health malathion organic food food nutrition guidelines [SDV]Life Sciences [q-bio] Public Health Environmental and Occupational Health pesticides germany type 2 prevention exposure thiabendazole diabetes mellitus follow-up diet
Zdroj:	14th European Public Health Conference Public health futures in a changing world 14th European Public Health Conference Public health futures in a changing world, Nov 2021, on-line, France. ⟨10.1093/eurpub/ckab164.341⟩
Popis:	Background Many modifiable risk factors have been identified for type 2 diabetes. However, emerging risk factors such as food contaminants could also play a role and studies are lacking on the subject. We aimed to assess the prospective associations between dietary pesticide exposure profiles and Type 2 Diabetes (T2D) risk among NutriNet-Santé cohort participants. Methods In 2014, participants completed a Food Frequency Questionnaire, assessing conventional and organic food consumption. Exposures to 25 active substances were estimated using a residue database accounting for farming practices from Chemisches und Veterinäruntersuchungsamt Stuttgart, Germany. Exposure profiles were established using Non-Negative Matrix Factorization (NMF), adapted for sparse data. Cox models adjusted for confounding factors were used to estimate hazard ratios (HR) and 95% confidence interval (95% CI), for the association between the four obtained NMF components and T2D risk. Results The sample comprised 33,013 participants aged 53 years old on average, among which 76% of women. During follow-up (median: 5.95 years), 340 incident T2D cases were diagnosed. Positive associations were detected between NMF component 1 (reflecting high exposure to azoxystrobin, chlorpyriphos, imazalil, malathion, profenofos, thiabendazole) and T2D risk: HRQ5 vs Q1=1.47, 95% CI(1.00, 2.18). NMF Component 3 (reflecting low exposure to several synthetic pesticides) was associated with a decrease in T2D risk, among those with high dietary quality only (high adherence to French dietary guidelines): HRQ5vsQ1=0.31, 95%CI(0.10, 0.94). No associations were found for NMF Components 2 and 4. Conclusions These associations between some pesticide mixtures and T2D diabetes risk need to be confirmed in other types of studies and settings. These results could have important implications for developing prevention strategies, through regulations or dietary guidelines. Key messages Specific pesticide mixtures could play a role in increased type 2 Diabetes risk. Organic eaters were less exposed to most synthetic pesticides.
Databáze:	OpenAIRE
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