IgA Anti-transglutaminase Autoantibodies at Type 1 Diabetes Onset Are Less Frequent in Adult Patients and Are Associated With a General Celiac-Specific Lower Immune Response in Comparison With Nondiabetic Celiac Patients at Diagnosis
| Autor: | Andrea Lenzi, Susanna Morano, Blegina Shashaj, Margherita Bonamico, Federica Lucantoni, Francesco Costantino, Francesca Panimolle, Tiziana Filardi, Claudio Tiberti, Raffaella Nenna |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Immunoglobulin A
musculoskeletal diseases Adult Male congenital hereditary and neonatal diseases and abnormalities Adolescent Tissue transglutaminase Endocrinology Diabetes and Metabolism Immune system Diabetes mellitus Internal Medicine medicine Humans Age of Onset Pathophysiology/Complications Child Original Research Aged Autoantibodies Advanced and Specialized Nursing Type 1 diabetes Transglutaminases biology business.industry Autoantibody Infant Middle Aged medicine.disease Celiac Disease Diabetes Mellitus Type 1 Child Preschool Immunology biology.protein Female Age of onset Antibody business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To evaluate the celiac-associated humoral autoimmunity in child, adolescent, and adult patients at type 1 diabetes (DM1) onset and to determine whether DM1 celiac-specific humoral immunoreactivity occurs similarly to that in nondiabetic patients at celiac disease (CD) diagnosis. RESEARCH DESIGN AND METHODS IgA anti-transglutaminase autoantibody (IgA-tTGAb) was detected in 654 new-onset DM1 sera. IgA-tTGAb+ DM1 sera were subsequently analyzed for IgG-tTG, deamidated gliadin (DGP), and actin antibodies, and results were compared with those found in 83 screen-detected nondiabetic patients at CD diagnosis. RESULTS A total of 12.8% DM1 sera were IgA-tTGAb+, with a lower autoantibody frequency in adult patients aged >18 years (6.8 vs. 15.1%, aged ≤18 years; P = 0.005). IgA-tTGAb titers, IgG-tTGAb, and DGPAb frequency/titers and mean number of celiac-autoantibody positivities per patient were significantly lower in IgA-tTGAb+ DM1 compared with nondiabetic CD patients. CONCLUSIONS Age of diabetes onset is negatively associated with risk of CD. The celiac-specific humoral immunoreactivity at DM1 onset is significantly lower compared with that found in nondiabetic patients at CD diagnosis. |
| Databáze: | OpenAIRE |
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