The impact of not having a ductus arteriosus on clinical outcomes in foetuses diagnosed with tetralogy of Fallot
| Autor: | Seth J. Stern, Lynne E. Nield, Brian W. McCrindle, Cedric Manlhiot, Neelum Wadekar, Edgar Jaeggi, Luc Mertens |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Gestational Age Aortic arches Young Adult Pregnancy Prenatal Diagnosis Ductus arteriosus Internal medicine medicine.artery medicine Humans cardiovascular diseases Ductus Arteriosus Patent Tetralogy of Fallot Ontario business.industry Infant Newborn Gestational age General Medicine Hospitals Pediatric medicine.disease Sick child Catheter Treatment Outcome medicine.anatomical_structure Echocardiography Case-Control Studies Pulmonary valve embryonic structures Pediatrics Perinatology and Child Health Pulmonary artery cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Cardiology in the Young. 25:684-692 |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Background: Foetuses with simple tetralogy of Fallot almost universally have a patent ductus arteriosus. Two recently identified cases had an absent patent ductus arteriosus, requiring emergent intervention at birth. The objective of this study was to determine whether foetuses diagnosed with tetralogy of Fallot and no patent ductus arteriosus have poorer outcomes compared with those with tetralogy of Fallot+patent ductus arteriosus. Methods: All foetal cases of tetralogy of Fallot between January, 2000 and 2012 were retrospectively identified from The Hospital for Sick Children (Toronto, Canada) database. Cases – tetralogy of Fallot+no patent ductus arteriosus confirmed on postnatal echo – and controls – tetralogy of Fallot+patent ductus arteriosus, matched for gestational age – were identified from prenatal records, and both clinical and echocardiographic data were reviewed. Optimal outcome was defined as valve-sparing repair with no residual lesions. Student’s t-tests and Fisher’s exact χ2 were used to compare groups. Results: n=115 foetuses were diagnosed with tetralogy of Fallot: 11 (9%) had no patent ductus arteriosus, and were matched to 22 controls – mean gestational age at diagnosis 23.2±4.2 weeks, 23.4±6.6 weeks, respectively. Cases had a higher proportion of right aortic arches (64% versus 14%, pConclusions: The patent ductus arteriosus does not appear to have an impact on clinical outcome in foetuses with tetralogy of Fallot. |
| Databáze: | OpenAIRE |
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