Effects of Cardiac Resynchronization Therapy on Ventricular Electrical Remodeling in Patients With Heart Failure
| Autor: | Qiang Xing, Jianghua Zhang, Yu Zhang, Baopeng Tang, Xianhui Zhou, Jinxin Li, Yaodong Li |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
China medicine.medical_specialty Heart Ventricles medicine.medical_treatment Cardiac resynchronization therapy Cardiac Resynchronization Therapy Electrocardiography QRS complex Heart Conduction System Risk Factors Internal medicine medicine Humans cardiovascular diseases Ventricular remodeling Aged Heart Failure Ischemic cardiomyopathy Ventricular Remodeling business.industry Dilated cardiomyopathy Organ Size General Medicine Middle Aged medicine.disease Survival Analysis Treatment Outcome Echocardiography Heart failure cardiovascular system Cardiology Female Electrical conduction system of the heart Cardiology and Cardiovascular Medicine business Follow-Up Studies circulatory and respiratory physiology Intrinsic QRS Duration |
| Zdroj: | International Heart Journal. 56:495-499 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.15-104 |
| Popis: | Cardiac resynchronization therapy (CRT) reverses structural remodeling of the left ventricle. We investigated whether CRT reverses left-ventricular electrical remodeling.Eighty patients were enrolled and implanted with CRT-devices. Echocardiography and electrocardiography data were obtained from each patient prior to implantation and two years after implantation. At two years after implantation, the patients were classified into a responder group and a non-responder group based on echocardiography.Over the next 2 years, 75 patients completed follow-up, and 5 patients had died. Echocardiography results showed that 23 patients could be classified as non-responders and 52 as responders. Larger numbers of non-responders were diagnosed with either ischemic cardiomyopathy (ICM) or nonspecific intraventricular conduction delay (NICD). The intrinsic QRS duration was not changed in responders, patients with dilated cardiomyopathy, or in the patient categories of male and female. However, the intrinsic QRS duration was significantly prolonged in non-responders and patients with ischemic cardiomyopathy (P = 0.041). The mean left ventricular end-diastolic diameter in the responder group was significantly decreased by CRT (P < 0.05), while there was no significant change in intrinsic QRS duration.While CRT does not reduce the intrinsic QRS duration, it can delay negative ventricular electrical remodeling. Continuous CRT is necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|