Neuropeptide Y, stressful life events and personality trait conscientiousness: Preliminary associations from a Swedish longitudinal study
| Autor: | Philippe A. Melas, Peter Guban, Catharina Lavebratt, Yvonne Forsell, Shafiqur Rahman |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Longitudinal study media_common.quotation_subject Biology Polymorphism Single Nucleotide Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders Humans Personality SNP Neuropeptide Y Amino Acid Sequence Longitudinal Studies Protein Precursors Promoter Regions Genetic Gene Alleles Biological Psychiatry media_common Sweden Genetics Genetic Variation Conscientiousness Middle Aged Heritability Neuropeptide Y receptor Sociological Factors humanities Psychiatry and Mental health 030104 developmental biology Trait Female Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research. 263:48-53 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2018.02.041 |
| Popis: | The heritability of the Five-Factor Model (FFM) of human personality is high, but few genes have been identified to underlie FFM traits. Neuropeptide Y (NPY) is a pleiotropic gene implicated in stress resilience that contains two well-studied functional SNPs: (1) rs16147, which lies in the NPY promoter and affects expression levels, and (2) rs16139, which lies in the coding sequence of NPY's precursor peptide, pre-pro NPY, and affects precursor processing. In the present study we examined whether these two polymorphisms are associated with FFM traits, using a Swedish cohort (rs16147, N = 2113; and rs16139, N = 1971), and found a significant association with rs16139. Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness. Next, we looked at exposure to life adversities, both in childhood and adulthood, and found that stressful life events were significantly associated with reduced levels of conscientiousness. These data provide insights into the neurobiology of human personality. However, given the difficulty in replicating genetic and environmental associations with behaviorally complex traits, these findings should be considered preliminary and warrant replication in additional cohorts. |
| Databáze: | OpenAIRE |
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