A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome
| Autor: | Raymond R. Samaha, Harry F. Noller, Rachel Green |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Base Composition
Multidisciplinary Peptidyl transferase Base Sequence Base pair Molecular Sequence Data information science Ribosomal RNA Biology Ribosome RNA Bacterial RNA Ribosomal 23S RNA Transfer Biochemistry Mutagenesis 23S ribosomal RNA Peptidyl Transferases Transfer RNA Escherichia coli biology.protein Nucleic Acid Conformation P-site T arm Ribosomes Conserved Sequence |
| Zdroj: | Nature. 377:309-314 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Interaction of the conserved CCA terminus of tRNA with rRNA in the peptidyl transferase P site has been studied by in vitro genetics. A watson-Crick G-C pair between G2252 in a conserved hairpin loop of 23S rRNA and C74 at the acceptor end of tRNA is required for proper functional interaction of the CCA end of tRNA with the ribosomal P site. These findings establish a direct role for 23S rRNA in protein synthesis. |
| Databáze: | OpenAIRE |
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