Experimental Argentine Hemorrhagic Fever in Rhesus Macaques: Viral Strain-Dependent Clinical Response
| Autor: | Eddy Ga, C. J. Peters, Julio I. Maiztegui, B. G. Mahlandt, Kelly T. McKee |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Oropharynx
Hemorrhage Disease Biology Antibodies Viral Argentine hemorrhagic fever Hemorrhagic Fever American Virus Pathogenesis Species Specificity Neutralization Tests medicine Animals Immunology and Allergy Viremia Arenaviridae Arenaviruses New World Purpura Strain (biology) medicine.disease biology.organism_classification Macaca mulatta Virology Disease Models Animal Hemorrhagic Fevers Infectious Diseases Junin virus Immunology Viral disease Nervous System Diseases |
| Zdroj: | Journal of Infectious Diseases. 152:218-221 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/152.1.218 |
| Popis: | Recently, we evaluated rhesus macaques as a potential disease model for AHF. Three of four low-passage strains of Junin virus that were administered to these animals produced severe disease accurately reflected the clinical features of human AHF. These studies establish the utility of Macacca mulatta as a model for human infection with Junin virus and suggest that differences in virus strains may influence patterns of biologic response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|