Ethylene Oxide Exposure in U.S. Populations Residing Near Sterilization and Other Industrial Facilities: Context Based on Endogenous and Total Equivalent Concentration Exposures
| Autor: | Ryan C. Lewis, Heather N. Watson, Christopher R. Kirman, Patrick J. Sheehan, James S. Bus, Eric D Winegar |
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| Rok vydání: | 2020 |
| Předmět: |
Ethylene Oxide
exposure science Percentile Health Toxicology and Mutagenesis Population total equivalent concentration lcsh:Medicine Endogeny exposure metrics 010501 environmental sciences Context based 01 natural sciences Article Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Manufacturing and Industrial Facilities Cancer risk assessment Humans 030212 general & internal medicine United States Environmental Protection Agency education 0105 earth and related environmental sciences education.field_of_study Ethylene oxide lcsh:R Public Health Environmental and Occupational Health Sterilization Environmental Exposure endogenous equivalent concentration Sterilization (microbiology) United States exposure contextualization chemistry Equivalent concentration |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 607, p 607 (2021) Volume 18 Issue 2 |
| ISSN: | 1660-4601 |
| Popis: | Given ubiquitous human exposure to ethylene oxide (EO), regardless of occupation or geography, the current risk-specific concentrations (RSCs: 0.0001&ndash 0.01 ppb) from the U.S. Environmental Protection Agency (EPA) cancer risk assessment for EO are not useful metrics for managing EO exposures to the general U.S. population. The magnitude of the RSCs for EO are so low, relative to typical endogenous equivalent metabolic concentrations (1.1&ndash 5.5 ppb) that contribute ~93% of total exposure, that the RSCs provide little utility in identifying excess environmental exposures that might increase cancer risk. EO monitoring data collected in the vicinity of eight EO-emitting facilities and corresponding background locations were used to characterize potential excess exogenous concentrations. Both 50th and 90th percentile exogenous exposure concentrations were combined with the 50th percentile endogenous exposure concentration for the nonsmoking population, and then compared to percentiles of total equivalent concentration for this population. No potential total exposure concentration for these local populations exceeded the normal total equivalent concentration 95th percentile, indicating that excess facility-related exposures are unlikely to require additional management to protect public health. |
| Databáze: | OpenAIRE |
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