Genetic variants associated with exercise performance in both moderately trained and highly trained individuals
| Autor: | Nir Eynon, Kevin J. Ashton, Xu Yan, Nicholas R Harvey, Ioannis D. Papadimitriou, Sarah Voisin, Macsue Jacques, Paul J. Dunn, Luke J. Haseler, Heidi G. Sutherland, Larisa M. Haupt, Lyn R. Griffiths |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0106 biological sciences 0301 basic medicine Oncology medicine.medical_specialty Genotype education Population Single-nucleotide polymorphism Athletic Performance Biology Polymorphism Single Nucleotide 01 natural sciences 03 medical and health sciences Time trial Internal medicine Genetic variation Genetics medicine Humans Lactic Acid Allele Exercise Molecular Biology education.field_of_study Genome Human Lactate threshold VO2 max General Medicine Adaptation Physiological 030104 developmental biology Cohort Physical Endurance 010606 plant biology & botany |
| Zdroj: | Molecular Genetics and Genomics. 295:515-523 |
| ISSN: | 1617-4623 1617-4615 |
| DOI: | 10.1007/s00438-019-01639-8 |
| Popis: | Adaptation to exercise training is a complex trait that may be influenced by genetic variants. We identified 36 single nucleotide polymorphisms (SNPs) that had been previously associated with endurance or strength performance, exercise-related phenotypes or exercise intolerant disorders. A MassARRAY multiplex genotyping assay was designed to identify associations with these SNPs against collected endurance fitness phenotype parameters obtained from two exercise cohorts (Gene SMART study; n = 58 and Hawaiian Ironman Triathlon 2008; n = 115). These parameters included peak power output (PP), a time trial (TT), lactate threshold (LT), maximal oxygen uptake (VO2 max) in recreationally active individuals and a triathlon time-to-completion (Hawaiian Ironman Triathlon cohort only). A nominal significance threshold of α |
| Databáze: | OpenAIRE |
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