Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Autor: Coleman, Jonathan RI, Peyrot, Wouter J, Purves, Kirstin L, Davis, Katrina AS, Rayner, Christopher, Choi, Shing Wan, Hubel, Christopher, Gaspar, Helena A, Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M, Choi, Karmel W, Dunn, Erin C, Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J, Lewis, Cathryn M, O'Reilly, Paul F, McIntosh, Andrew M, Smith, Daniel J, Wray, Naomi R, Hotopf, Matthew, Eley, Thalia C, Breen, Gerome, Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Andlauer, Till FM, Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan TF, Bigdeli, Tim B, Binder, Elisabeth B, Bryois, Julien, Buttenschon, Henriette N, Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E, Davies, Gail, Deary, Ian J, Degenhardt, Franziska, Derks, Eske M, Direk, Nese, Dolan, Conor V, Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K, Foo, Jerome C, Forstner, Andreas J, Frank, Josef, Gill, Michael, Goes, Fernando S, Gordon, Scott D, Grove, Jakob, Hall, Lynsey S, Hansen, Christine Soholm, Hansen, Thomas F, Herms, Stefan, Hickie, Ian B, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Hougaard, David M, Howard, David M, Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A, Jorgenson, Eric, Knowles, James A, Kohane, Isaac S, Kraft, Julia, Kretzschmar, Warren W, Kutalik, Zoltan, Li, Yihan, Lind, Penelope A, MacIntyre, Donald J, MacKinnon, Dean F, Maier, Robert M, Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E, Mehta, Divya, Middeldorp, Christel M, Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M, Montgomery, Grant W, Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G, Nyholt, Dale R, Oskarsson, Hogni, Owen, Michael J, Painter, Jodie N, Pedersen, Carsten Bocker, Pedersen, Marianne Giortz, Peterson, Roseann E, Pettersson, Erik, Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A, Qvist, Per, Rice, John P, Riley, Brien P, Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C, Shen, Ling, Shi, Jianxin, Shyn, Stanley I, Sigurdsson, Engilbert, Sinnamon, Grant CB, Smit, Johannes H, Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E, Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, Andres G, Umbricht, Daniel, van Hemert, Albert M, Viktorin, Alexander, Visscher, Peter M, Wang, Yunpeng, Webb, Bradley T, Weinsheimer, Shantel Marie, Wellmann, Jurgen, Willemsen, Gonneke, Witt, Stephanie H, Wu, Yang, Xi, Hualin S, Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I, Cichon, Sven, Dannlowski, Udo, de Geus, EJC, DePaulo, J Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tonu, Hamilton, Steven P, Hayward, Caroline, Heath, Andrew C, Kendler, Kenneth S, Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S, Lucae, Susanne, Madden, Pamela AF, Magnusson, Patrik K, Martin, Nicholas G, Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Nordentoft, Merete, Noethen, Markus M, O'Donovan, Michael C, Paciga, Sara A, Pedersen, Nancy L, Penninx, Brenda WJH, Perlis, Roy H, Porteous, David J, Potash, James B, Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G, Smoller, Jordan W, Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Volzke, Henry, Weissman, Myrna M, Werge, Thomas, Levinson, Douglas F, Borglum, Anders D, Sullivan, Patrick F, Consortium, Psychiat Genomics
Přispěvatelé: Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), Human genetics, APH - Methodology, APH - Digital Health, Adult Psychiatry, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Sociology and Social Gerontology, Complex Trait Genetics, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Adams, M.J., Agerbo, E., Air, T.M., Andlauer, TFM, Bacanu, S.A., Bækvad-Hansen, M., Beekman, ATF, Bigdeli, T.B., Binder, E.B., Bryois, J., Buttenschøn, H.N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J.H., Clarke, T.K., Coleman, JRI, Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G.E., Davies, G., Deary, I.J., Degenhardt, F., Derks, E.M., Direk, N., Dolan, C.V., Dunn, E.C., Eley, T.C., Escott-Price, V., Kiadeh, FFH, Finucane, H.K., Foo, J.C., Forstner, A.J., Frank, J., Gaspar, H.A., Gill, M., Goes, F.S., Gordon, S.D., Grove, J., Hall, L.S., Hansen, C.S., Hansen, T.F., Herms, S., Hickie, I.B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J.J., Hougaard, D.M., Howard, D.M., Ising, M., Jansen, R., Jones, I., Jones, L.A., Jorgenson, E., Knowles, J.A., Kohane, I.S., Kraft, J., Kretzschmar, W.W., Kutalik, Z., Li, Y., Lind, P.A., MacIntyre, D.J., MacKinnon, D.F., Maier, R.M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S.E., Mehta, D., Middeldorp, C.M., Mihailov, E., Milaneschi, Y., Milani, L., Mondimore, F.M., Montgomery, G.W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M.G., Nyholt, D.R., O'Reilly, P.F., Oskarsson, H., Owen, M.J., Painter, J.N., Pedersen, C.B., Pedersen, M.G., Peterson, R.E., Pettersson, E., Peyrot, W.J., Pistis, G., Posthuma, D., Quiroz, J.A., Qvist, P., Rice, J.P., Riley, B.P., Rivera, M., Mirza, S.S., Schoevers, R., Schulte, E.C., Shen, L., Shi, J., Shyn, S.I., Sigurdsson, E., Sinnamon, GCB, Smit, J.H., Smith, D.J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K.E., Teismann, H., Teumer, A., Thompson, W., Thomson, P.A., Thorgeirsson, T.E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A.G., Umbricht, D., Van der Auwera, S., van Hemert, A.M., Viktorin, A., Visscher, P.M., Wang, Y., Webb, B.T., Weinsheimer, S.M., Wellmann, J., Willemsen, G., Witt, S.H., Wu, Y., Xi, H.S., Yang, J., Zhang, F., Arolt, V., Baune, B.T., Berger, K., Boomsma, D.I., Cichon, S., Dannlowski, U., de Geus, EJC, DePaulo, J.R., Domenici, E., Domschke, K., Esko, T., Grabe, H.J., Hamilton, S.P., Hayward, C., Heath, A.C., Kendler, K.S., Kloiber, S., Lewis, G., Li, Q.S., Lucae, S., Madden, PAF, Magnusson, P.K., Martin, N.G., McIntosh, A.M., Metspalu, A., Mors, O., Mortensen, P.B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M.M., O'Donovan, M.C., Paciga, S.A., Pedersen, N.L., Penninx, BWJH, Perlis, R.H., Porteous, D.J., Potash, J.B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T.G., Smoller, J.W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M.M., Werge, T., Lewis, C.M., Levinson, D.F., Breen, G., Børglum, A.D., Sullivan, P.F.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Netherlands Twin Register (NTR)
0301 basic medicine
Male
SYMPTOMS
Databases
Factual
Genome-wide association study
0302 clinical medicine
Medicine
Depression (differential diagnoses)
RISK
HERITABILITY
PSYCHIATRIC-DISORDERS
Middle Aged
Psychiatry and Mental health
Major depressive disorder
Female
Waist Circumference
MENTAL-HEALTH
Psychological trauma
Clinical psychology
Adult
Psychological Trauma
Genetic correlation
CHILDHOOD MALTREATMENT
Article
EVENTS
03 medical and health sciences
Cellular and Molecular Neuroscience
SDG 3 - Good Health and Well-being
ADVERSITY
mental disorders
SNP
Humans
Genetic Predisposition to Disease
Molecular Biology
Genetic association
Aged
Depressive Disorder
Major
business.industry
Heritability
medicine.disease
United Kingdom
ASSOCIATION ANALYSIS
030104 developmental biology
BIOLOGICAL INSIGHTS
Gene-Environment Interaction
Self Report
business
030217 neurology & neurosurgery
Genome-Wide Association Study
Zdroj: Coleman, J R I, Peyrot, W J, Purves, K, Davis, K A S, Rayner, C, Choi, S W, Huebel, C, Gaspar, H A, Kan, C, der Auwera, S V, Adams, M J, Lyall, D, Choi, K W, Dunn, E C, Vassos, E, Danese, A, Maughan, B, Grabe, H J, Lewis, C M, O'Reilly, P F, McIntosh, A M, Smith, D J, Wray, N R, Hotopf, M, Eley, T & Breen, G & Howard, D 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry, vol. 25, no. 7, pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6
Molecular Psychiatry, 25, 1430-1446. NATURE PUBLISHING GROUP
Molecular psychiatry
Coleman, J R I & Adams, M J & McIntosh, A 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry . https://doi.org/10.1038/s41380-019-0546-6
MOLECULAR PSYCHIATRY
Molecular Psychiatry, 25(7), 1430-1446. Nature Publishing Group
Coleman, J R I, Peyrot, W J, Purves, K L, Davis, K A S, Rayner, C, Choi, S W, Hübel, C, Gaspar, H A, Kan, C, Van der Auwera, S, Adams, M J, Lyall, D M, Choi, K W, Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T F M, Bacanu, S A, Bækvad-Hansen, M, Beekman, A T F, Bigdeli, T B, Binder, E B, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T K, Coleman, J R I, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, Direk, N, Dolan, C V, Dunn, E C, Eley, T C, Escott-Price, V, Kiadeh, F F H, Finucane, H K, Foo, J C, Forstner, A J, Frank, J, Gaspar, H A, Gill, M, Goes, F S, Gordon, S D, Grove, J, Hall, L S, Hansen, C S, Hansen, T F, Herms, S, Hickie, I B, Hoffmann, P, Homuth, G, Horn, C, Hottenga, J J, Hougaard, D M, Howard, D M, Ising, M, Jansen, R, Jones, I, Jones, L A, Jorgenson, E, Knowles, J A, Kohane, I S, Kraft, J, Kretzschmar, W W, Kutalik, Z, Li, Y, Lind, P A, MacIntyre, D J, MacKinnon, D F, Maier, R M, Maier, W, Marchini, J, Mbarek, H, McGrath, P, McGuffin, P, Medland, S E, Mehta, D, Middeldorp, C M, Mihailov, E, Milaneschi, Y, Milani, L, Mondimore, F M, Montgomery, G W, Mostafavi, S, Mullins, N, Nauck, M, Ng, B, Nivard, M G, Nyholt, D R, O’Reilly, P F, Oskarsson, H, Owen, M J, Painter, J N, Pedersen, C B, Pedersen, M G, Peterson, R E, Pettersson, E, Peyrot, W J, Pistis, G, Posthuma, D, Quiroz, J A, Qvist, P, Rice, J P, Riley, B P, Rivera, M, Mirza, S S, Schoevers, R, Schulte, E C, Shen, L, Shi, J, Shyn, S I, Sigurdsson, E, Sinnamon, G C B, Smit, J H, Smith, D J, Stefansson, H, Steinberg, S, Streit, F, Strohmaier, J, Tansey, K E, Teismann, H, Teumer, A, Thompson, W, Thomson, P A, Thorgeirsson, T E, Traylor, M, Treutlein, J, Trubetskoy, V, Uitterlinden, A G, Umbricht, D, Van der Auwera, S, van Hemert, A M, Viktorin, A, Visscher, P M, Wang, Y, Webb, B T, Weinsheimer, S M, Wellmann, J, Willemsen, G, Witt, S H, Wu, Y, Xi, H S, Yang, J, Zhang, F, Arolt, V, Baune, B T, Berger, K, Boomsma, D I, Cichon, S, Dannlowski, U, de Geus, E J C, DePaulo, J R, Domenici, E, Domschke, K, Esko, T, Grabe, H J, Hamilton, S P, Hayward, C, Heath, A C, Kendler, K S, Kloiber, S, Lewis, G, Li, Q S, Lucae, S, Madden, P A F, Magnusson, P K, Martin, N G, McIntosh, A M, Metspalu, A, Mors, O, Mortensen, P B, Müller-Myhsok, B, Nordentoft, M, Nöthen, M M, O’Donovan, M C, Paciga, S A, Pedersen, N L, Penninx, B W J H, Perlis, R H, Porteous, D J, Potash, J B, Preisig, M, Rietschel, M, Schaefer, C, Schulze, T G, Smoller, J W, Stefansson, K, Tiemeier, H, Uher, R, Völzke, H, Weissman, M M, Werge, T, Lewis, C M, Levinson, D F, Breen, G, Børglum, A D, Sullivan, P F, Dunn, E C, Vassos, E, Danese, A, Maughan, B, Grabe, H J, Lewis, C M, O’Reilly, P F, McIntosh, A M, Smith, D J, Wray, N R, Hotopf, M, Eley, T C, Breen, G & on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry, vol. 25, no. 7, pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6
Coleman, J R I, Peyrot, W J, Purves, K L, Davis, K A S, Rayner, C, Choi, S W, Hubel, C, Gaspar, H A, Kan, C, Van der Auwera, S, Adams, M J, Lyall, D M, Choi, K W, Psychiat Genomics Consortium, Dunn, E C, Vassos, E, Danese, A, Maughan, B, Grabe, H J, Lewis, C M, O'Reilly, P F, McIntosh, A M, Smith, D J, Wray, N R, Hotopf, M, Eley, T C & Breen, G 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry, vol. 25, no. 7, pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6
Coleman, J R I, Peyrot, W J, Purves, K L, Davis, K A S, Rayner, C, Choi, S W, Hübel, C, Gaspar, H A, Kan, C, Van der Auwera, S, Adams, M J, Lyall, D M, Choi, K W, Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T F M, Bacanu, S A, Bækvad-Hansen, M, Beekman, A T F, Bigdeli, T B, Binder, E B, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T K, Coleman, J R I, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, Hansen, C S, Hansen, T F, Pedersen, C B, Pedersen, M G, Nordentoft, M, Werge, T & on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry, vol. 25, pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6
Molecular psychiatry, 25(7), 1430-1446. Nature Publishing Group
Coleman, J R I, Breen, G, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Abdellaoui, A, Dolan, C V, Hottenga, J J, Mbarek, H, Middeldorp, C M, Nivard, M G, Willemsen, G, Boomsma, D I, de Geus, E J C, Beekman, A T F, Jansen, R, Milaneschi, Y, Smit, J H, W J H Penninx, B & Posthuma, D 2020, ' Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank ', Molecular Psychiatry, vol. 25, no. 7, pp. 1430-1446 . https://doi.org/10.1038/s41380-019-0546-6
Molecular psychiatry, vol. 25, no. 7, pp. 1430-1446
ISSN: 1359-4184
Popis: Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD stratified by reported trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD with reported trauma exposure (24%) was greater than MDD without reported trauma exposure (12%). Simulations showed that this is not confounded by the strong, positive genetic correlation observed between MDD and reported trauma exposure. We also observed that the genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (r g = 0.24, p = 1.8 × 10 -7 versus r g = -0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3 × 10 -4 ). Our results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
Databáze: OpenAIRE
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