Cocaine hepatotoxicity during protein undernutrition of retrovirally infected mice
| Autor: | Maria C. Lopez, Olalekan E. Odeleye, Ronald R. Watson, Bruce T. Smith, Cleamond D. Eskelson |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Low protein Physiology medicine.medical_treatment Biology Protein-Energy Malnutrition Lipid peroxidation Mice chemistry.chemical_compound Cocaine Low-protein diet Physiology (medical) Internal medicine Murine leukemia virus medicine Animals Transaminases Triglycerides Pharmacology Liver injury Leukemia Experimental Protein undernutrition Retroviral infection Body Weight Organ Size General Medicine Lipid Metabolism medicine.disease Malondialdehyde biology.organism_classification Leukemia Virus Murine Mice Inbred C57BL Endocrinology Liver chemistry Immunology Steatitis Female Lipid Peroxidation Chemical and Drug Induced Liver Injury Retroviridae Infections |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 70:338-343 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | Effects of cocaine administration on lipid peroxidation and liver damage in immunocompromised mice fed different levels of dietary proteins were investigated. Indices of lipid peroxidation and serum aminotransferases as evidence of free radical attack and liver damage were compared in mice fed a low protein (4%) or regular protein diet (20% protein) for 3 weeks and then infected with murine leukemia virus and given daily intraperitoneal injections of increasing progressive doses of 5–45 mg∙kg−1∙day−1 of cocaine for 11 weeks. Cocaine administration significantly increased hepatic triglycerides, serum aminotransaminases, conjugated dienes, lipid fluorescence, and malondialdehyde levels. These changes were exacerbated by retroviral infection and also by protein undernutrition. Retroviral infection additiveiy increased indices of cocaine-induced lipid peroxidation and hepatic damage. Significant increases in indices of lipid peroxidation and greater liver injury were also detected in similarly treated mice that received the low protein diet compared with well-nourished mice. These results show that immunocompromised mice fed low levels of dietary protein form significantly increased immunogenic lipid peroxidation adducts during cocaine treatment.Key words: lipid peroxidation, retroviral infection, cocaine, protein nutrition, liver, AIDS. |
| Databáze: | OpenAIRE |
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