Synthesis of 2′,3′-Dideoxy-2′-Fluoro-l-threo-Pentofuranosyl Nucleosides as Potential Antiviral Agents
| Autor: | Yuejun Xiang, Raymond F. Schinazi, Yung-Chi Cheng, Chung K. Chu, Socrates C. H. Cavalcanti, M. G. Newton |
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| Rok vydání: | 1999 |
| Předmět: |
Hepatitis B virus
Stereochemistry Human immunodeficiency virus (HIV) virus diseases Nucleosides Stereoisomerism Virus Replication medicine.disease_cause Antiviral Agents Biochemistry Virology Structure-Activity Relationship chemistry.chemical_compound chemistry HIV-1 Genetics medicine Simplexvirus Derivative (chemistry) Cytosine |
| Zdroj: | Nucleosides and Nucleotides. 18:2233-2252 |
| ISSN: | 0732-8311 |
| DOI: | 10.1080/07328319908044878 |
| Popis: | A series of 2′,3′-dideoxy-2′-fluoro-L-threo-pentofuranosyl nucleosides has been synthesized as potential antiviral agents. The synthesized compounds were evaluated against HIV-1, HBV, HSV-1, and HSV-2. Among the synthesized analogues, only the cytosine derivative showed moderate antiviral activity against HIV and HBV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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