Delayed action of serotonin in molluscan development
| Autor: | Leonid P. Nezlin, Elena E. Voronezhskaya, Marina Yu. Khabarova, E. G. Ivashkin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Serotonin
biology Embryogenesis Embryonic Development Lymnaea stagnalis Anatomy biology.organism_classification General Biochemistry Genetics and Molecular Biology Freshwater snail Cell biology Neurology Gastropoda Animals Receptor Mollusca Locomotion Intracellular Lymnaea General Environmental Science |
| Zdroj: | Acta Biologica Hungarica. 63:210-216 |
| ISSN: | 1588-256X 0236-5383 |
| Popis: | Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT2-like type receptors are required for the appearence of these phenomena. |
| Databáze: | OpenAIRE |
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