Does Melanoma Begin in a Melanocyte Stem Cell?
| Autor: | Sarah Gilbert, Brandon Weiswasser, Alexandria Casillas, Albert Jiao, Danielle Chambers, James D. Hoerter, Lauren Clements, Patrick Bradley |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Dermatology
Review Article Melanocyte lcsh:RC254-282 03 medical and health sciences Cellular origin medicine Zebrafish 030304 developmental biology 0303 health sciences biology business.industry Melanoma 030302 biochemistry & molecular biology Mesenchymal stem cell fungi biology.organism_classification medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.anatomical_structure Oncology Immunology Cancer research Stem cell business UVB Radiation |
| Zdroj: | Journal of Skin Cancer Journal of Skin Cancer, Vol 2012 (2012) |
| ISSN: | 2090-2913 2090-2905 |
| Popis: | What is the cellular origin of melanoma? What role do melanocyte stem cells (MSC) and other melanocyte precursors play in the development of melanoma? Are MSCs and other latent melanocyte precursors more susceptible to solar radiation? These and many other questions can be very effectively addressed using the zebrafish model. Zebrafish have a robust regenerative capability, permitting the study of how MSCs are regulated and recruited at specific times and places to generate the pigment pattern following fin amputation or melanocyte ablation. They can be used to determine the effects of environmental radiation on the proliferation, survival, repair, and differentiation of MSCs. Our lab is using zebrafish to investigate how UVA- (320–400 nm) and UVB- (290–320 nm) induced damage to MSCs may contribute to the development of melanoma. A review is given of MSCs in zebrafish as well as experimental techniques and drugs for manipulating MSC populations. These techniques can be used to design experiments to help answer many questions regarding the role of MSCs or melanocyte precursors in the formation of melanoma stem cells and tumors following exposure to UVA/UVB radiation. |
| Databáze: | OpenAIRE |
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