Natriuretic Peptides and Normal Body Fluid Regulation
| Autor: | Peter Bie |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Body Fluids/physiology Vascular permeability 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Atrial natriuretic peptide Internal medicine Renin–angiotensin system Extracellular fluid medicine Animals Homeostasis Humans Natriuretic Peptides Water-Electrolyte Balance/physiology Aldosterone Chemistry Natriuretic Peptides/metabolism Water-Electrolyte Balance Brain natriuretic peptide Body Fluids 030104 developmental biology Endocrinology cardiovascular system Biomarkers hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Comprehensive Physiology Bie, P 2018, ' Natriuretic peptides and normal body fluid regulation ', Comprehensive Physiology, vol. 8, no. 3, pp. 1211-1249 . https://doi.org/10.1002/cphy.c180002 |
| DOI: | 10.1002/cphy.c180002 |
| Popis: | Natriuretic peptides are structurally related, functionally diverse hormones. Circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are delivered predominantly by the heart. Two C-type natriuretic peptides (CNPs) are paracrine messengers, notably in bone, brain, and vessels. Natriuretic peptides act by binding to the extracellular domains of three receptors, NPR-A, NPR-B, and NPR-C of which the first two are guanylate cyclases. NPR-C is coupled to inhibitory proteins. Atrial wall stress is the major regulator of ANP secretion; however, atrial pressure changes plasma ANP only modestly and transiently, and the relation between plasma ANP and atrial wall tension (or extracellular volume or sodium intake) is weak. Absence and overexpression of ANP-related genes are associated with modest blood pressure changes. ANP augments vascular permeability and reduces vascular contractility, renin and aldosterone secretion, sympathetic nerve activity, and renal tubular sodium transport. Within the physiological range of plasma ANP, the responses to step-up changes are unimpressive; in man, the systemic physiological effects include diminution of renin secretion, aldosterone secretion, and cardiac preload. For BNP, the available evidence does not show that cardiac release to the blood is related to sodium homeostasis or body fluid control. CNPs are not circulating hormones, but primarily paracrine messengers important to ossification, nervous system development, and endothelial function. Normally, natriuretic peptides are not powerful natriuretic/diuretic hormones; common conclusions are not consistently supported by hard data. ANP may provide fine-tuning of reno-cardiovascular relationships, but seems, together with BNP, primarily involved in the regulation of cardiac performance and remodeling. © 2017 American Physiological Society. Compr Physiol 8:1211-1249, 2018. |
| Databáze: | OpenAIRE |
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