Additional file 12 of Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells

Autor: Glasstetter, Logan M., Oderinde, Tomiwa S., Mirchandani, Mohit, Rajagopalan, Kamalnath Sankaran, Barsom, Samer H., Thaler, Roman, Siddiqi, Sarosh, Zhu, Xiang-Yang, Tang, Hui, Jordan, Kyra L., Saadiq, Ishran M., van Wijnen, Andre J., Eirin, Alfonso, Lerman, Lilach O.
Rok vydání: 2023
DOI: 10.6084/m9.figshare.23207974
Popis: Additional file 12: Figure S11. Obesity-driven dysregulation of 5hmC levels on genes related to cell population proliferation in human MSCs. A Volcano plot showing differential 5hmC levels in human Obese- versus Lean-MSCs for genes filtered by the GO term for cell population proliferation. For a given gene, differential 5hmC levels entail p-value ≤ 0.05 and fold change ≥ 1.4 or ≤ 0.7. Genes with high or low 5hmC levels in Obese-MSCs versus Lean-MSCs are represented with red or blue markers, respectively. B Heat maps of genes filtered by cell population proliferation showing lower or higher 5hmC levels in human Obese-MSCs versus human Lean-MSCs.
Databáze: OpenAIRE