Efficacy and safety of tirofiban injection with intracranial stenting in early reocclusion due to intracranial atherosclerosis
| Autor: | Jae-Sang Oh, Jae-Min Ahn, Dong Seong Shin, Jung Ho Ko, Jai-Joon Shim, Yu Jin Ha, Ji Young Lee, Yun Ho Noh, Man Ryul Lee, Seok-Mann Yoon, Jaewoo Chung, Hyuk-Jin Oh |
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| Rok vydání: | 2022 |
| Předmět: |
Tirofiban Injection
Ischemic stroke Percutaneous RD1-811 Heart disease business.industry Thrombosis Tirofiban Transluminal Angioplasty medicine.disease Mechanical thrombectomy Intracranial arteriosclerosis Anesthesia medicine Surgery In patient Neurology. Diseases of the nervous system Neurology (clinical) Intracranial Atherosclerosis RC346-429 business Thrombectomy medicine.drug |
| Zdroj: | Interdisciplinary Neurosurgery, Vol 27, Iss, Pp 101425-(2022) |
| ISSN: | 2214-7519 |
| Popis: | Objective: We aimed to develop an optimal protocol for failed mechanical thrombectomy (MT) in cases of emergent large vessel occlusion (ELVO) with intracranial atherosclerosis (ICAS). Methods: A total of 117 patients without underlying heart disease who were not taking antiplatelet drugs had early reocclusion during MT for ELVO due to ICAS. They were divided into the following 3 groups according to rescue treatment methods: 1) Combined intravenous (IV) + intra-arterial (IA) tirofiban group (n = 48), emergent percutaneous transluminal angioplasty (PTA) and intracranial stenting (ICS) followed by IA injection of tirofiban and a continuous IV tirofiban infusion for 8 h; 2) IA tirofiban group (n = 33), only IA 0.5–1.0 mg tirofiban infusion for 5 min regardless of PTA or ICS; and 3) no tirofiban group (n = 36), no tirofiban injection regardless of PTA or ICS. Results: ICS was more frequently performed in the combined IV + IA tirofiban group than in the IA tirofiban group (100% vs 46%, p |
| Databáze: | OpenAIRE |
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