Pregnancy outcomes regarding maternal serum AFP value in second trimester screening
| Autor: | Juozas Kurmanavicius, Josef Wisser, D. Balsyte, Karolina Bartkute |
|---|---|
| Přispěvatelé: | University of Zurich, Bartkute, Karolina |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Complications of pregnancy 610 Medicine & health 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Pregnancy medicine Humans 2735 Pediatrics Perinatology and Child Health 030212 general & internal medicine Pregnancy outcomes 10026 Clinic for Obstetrics Retrospective Studies Gynecology Fetus 030219 obstetrics & reproductive medicine business.industry Obstetrics Ultrasound Obstetrics and Gynecology Gestational age 2729 Obstetrics and Gynecology medicine.disease digestive system diseases Second trimester screening Pregnancy Trimester Second Pediatrics Perinatology and Child Health embryonic structures Small for gestational age Female alpha-Fetoproteins business Biomarkers |
| Popis: | Aim: The aim of this study was to evaluate the predictive value of α-fetoprotein in maternal serum (MS-AFP) as a marker for diverse pregnancy outcomes. Methods: The study was based on pregnancy and delivery data from 5520 women between 1999 and 2014 at University Hospital of Zurich (UHZ). Inclusion criteria: both MS-AFP and pregnancy outcome were known for the same pregnancy. Pregnancy outcomes and characteristics such as fetal malformation, intrauterine fetal death (IUFD) and intrauterine growth retardation as well as maternal age, weight before pregnancy, gestational age (GA) at delivery, newborn weight, length and head circumference were analyzed with respect to the MS-AFP value. MS-AFP value was categorized into three groups: elevated MS-AFP>2.5 multiples of the median (MoM), normal 0.5–2.49 MoM and decreased Results: Newborn weight (g) and length (cm) were significantly lower in the elevated MS-AFP (P Conclusion: MS-AFP level in the second trimester is still an important indicator of fetal surface malformations; however, ultrasound still outweighs as a screening method. Nevertheless, pregnant women with elevated MS-AFP values and with no sonographically detected fetal malformations should additionally receive the third trimester ultrasound examination to exclude other possible complications of pregnancy. |
| Databáze: | OpenAIRE |
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