Gastrokine 1 mRNA in human sera is not informative biomarker for gastric cancer

Autor: Filomena Altieri, Emilia Rippa, Giuseppina Miselli, Valentina Villano, Chiara Stella Di Stadio, Maurizio De Palma, Antonella Federico, Paolo Arcari
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Pathology
Absolute qRT-PCR
18 kDa antrum mucosal protein
Peptide Hormones
Statistical difference
Disease
Real-Time Polymerase Chain Reaction
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Pharmacology
Toxicology and Pharmaceutics(all)
0302 clinical medicine
Gastric cancer biomarker
Stomach Neoplasms
Internal medicine
medicine
Biomarkers
Tumor
Humans
RNA
Messenger
General Pharmacology
Toxicology and Pharmaceutics
Medicine(all)
Messenger RNA
Base Sequence
business.industry
Biochemistry
Genetics and Molecular Biology(all)
Brief Report
Cancer
General Medicine
Middle Aged
Serum samples
medicine.disease
Gastrokine 1
Gene Expression Regulation
Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Potential biomarkers
Healthy individuals
Case-Control Studies
Biomarker (medicine)
Female
business
Zdroj: Journal of Negative Results in Biomedicine
ISSN: 1477-5751
Popis: Background We aimed to ascertain if Gastrokine 1 mRNA in the sera of patients with gastric cancer might be an informative biomarker for the disease. Results Analysis of GKN1 mRNA in serum samples from healthy individuals (n = 23) and from patients with diagnosis of gastric cancer (n = 16), performed by using absolute quantification based on standard curve method, did not show any significative statistical difference between the two unpaired group of individuals. Conclusions Our preliminary results did not confirm GKN1 as a potential biomarker for gastric cancer.
Databáze: OpenAIRE
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