Meningeal tumor: A rare extrahepatic association in patients with polycystic liver disease enrolled for liver transplantation
| Autor: | Alexandre Bakonyi Neto, Marcelo Lopes Furtado, Amanda Pinter Cavalheiro da Silva, Marco Antonio Zanini, Camila César Winckler, Rodrigo Mattos dos Santos |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
medicine.medical_specialty liver transplantation business.industry Polycystic liver disease medicine.medical_treatment Cancer Articles Transplant Waiting List Liver transplantation medicine.disease Gastroenterology Molecular medicine meningioma Surgery Meningioma polycystic liver disease Oncology Internal medicine medicine Transitional Meningioma In patient business |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2013-08-12T19:10:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-05-01 Made available in DSpace on 2013-09-30T18:16:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-05-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:32:40Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:32:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-05-01 In the present study, we described a rare association of polycystic liver disease (PCLD) with intracranial meningiomas in patients included on a liver transplant list, focusing on the diagnosis, treatment and possible association with any genetic alterations. Two female patients, aged 39 and 49 years were included on a liver transplant list due to extensive PCLD, with symptoms related to an abdominal compartmental syndrome. Screening for extrahepatic manifestation revealed a right frontal meningioma in the first patient, and a parietal posterior calcified meningioma in the second patient, measuring 1 and 7x3x2 cm in diameter, respectively. Following tumor removal, the histological pattern was compatible with fibrous and transitional meningioma, respectively. Cytogenetic studies conducted following surgery did not reveal any changes in metaphase chromosomes. The postoperative follow-up for the two patients was uneventful, without complications, with the patients remaining on a liver transplant waiting list. We conclude that screening for extrahepatic manifestations of PCLD is mandatory, as certain lesions require treatment prior to liver transplantation. The lack of a genetic or familial association between these two cases show they are likely to have occurred by chance, rather than representing a previously unrecognized association between polycystic liver disease and cranial meningioma. UNESP, Botucatu Fac Med, Div Gastrointestinal Transplant, Dept Surg, Botucatu, SP, Brazil UNESP, Botucatu Fac Med, Dept Neurosurg, Botucatu, SP, Brazil UNESP, Botucatu Fac Med, Dept Urol, Botucatu, SP, Brazil UNESP, Botucatu Fac Med, Div Gastrointestinal Transplant, Dept Surg, Botucatu, SP, Brazil UNESP, Botucatu Fac Med, Dept Neurosurg, Botucatu, SP, Brazil UNESP, Botucatu Fac Med, Dept Urol, Botucatu, SP, Brazil |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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