Domperidone With ORT in the Treatment of Pediatric Acute Gastroenteritis in Japan
| Autor: | Hisashi Urushihara, Kenji Kishida, Yoshihiro Wakazono, Koji Kawakami, Shiro Hinotsu, Tatsutoshi Nakahata, Tetsuro Shimakawa, Eiko Yamauchi, Tohru Yorifuji, Hiroshi Sasaki, Fumiyo Kita |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Randomization Vomiting medicine.drug_class Administration Oral Suppository law.invention Japan Randomized controlled trial law Humans Medicine Antiemetic Prospective Studies Medical prescription Child business.industry Public Health Environmental and Occupational Health Infant Acute gastroenteritis Domperidone Gastroenteritis Child Preschool Anesthesia Acute Disease Antiemetics Fluid Therapy Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | Asia Pacific Journal of Public Health. 27:NP174-NP183 |
| ISSN: | 1941-2479 1010-5395 |
| DOI: | 10.1177/1010539511425701 |
| Popis: | Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan. In this study, the authors assessed the efficacy of domperidone prescription in combination with oral rehydration treatment (ORT) in the treatment of vomiting during acute gastroenteritis in children during the early period. They performed a prospective multicenter randomized trial in Japan. Patients received either ORT or ORT and domperidone prescription. The primary outcome was the proportion of patients who had vomiting during the first 2 hours after randomization. A total of 56 children were eligible; 24 received ORT alone, and 32 received ORT and prescribed domperidone suppository. Results showed that 27.3% of children in the ORT group vomited as compared with 20.7% of children in the ORT and domperidone group ( P = .41). In this study, it appears that domperidone in combination with ORT in the treatment of acute gastroenteritis does not reduce vomiting in the early period. |
| Databáze: | OpenAIRE |
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