Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model
| Autor: | Michael R. Gardner, Thomas E. Milner, Henry Grady Rylander, Ayesha S. Rahman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Retinal degeneration
Materials science genetic structures media_common.quotation_subject 01 natural sciences lcsh:RC321-571 010309 optics 03 medical and health sciences chemistry.chemical_compound Traumatic Brain Injury (TBI) and Chronic Traumatic Encephalopathy (CTE) 0302 clinical medicine Nuclear magnetic resonance Optical coherence tomography 0103 physical sciences medicine Contrast (vision) lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry mouse media_common Original Research Retina medicine.diagnostic_test Blood flow volume Scattering hypoxia General Neuroscience Retinal medicine.disease eye diseases medicine.anatomical_structure chemistry Mouse Retina angle-resolved imaging retinal imaging 030221 ophthalmology & optometry sense organs |
| Zdroj: | Journal of Experimental Neuroscience Journal of Experimental Neuroscience, Vol 13 (2019) |
| ISSN: | 1179-0695 |
| Popis: | Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution changes in retinal microstructure. SAR-OCT images of murine retinas that experience a hypoxic insult—euthanasia by isoflurane overdose—are presented. A total of 4 SAR-OCT measurement parameters are reported in 6 longitudinal experiments: blood flow volume fraction, total retinal thickness, reflectance index, and scattering angle. As each mouse expires, blood flow volume fraction decreases, total retinal thickness increases, reflectance index decreases, and scattering angle diversity increases. Contribution of the retinal vasculature to scattering angle diversity is discussed. Results of this study suggest the utility of SAR-OCT to measure TE using scattering angle diversity contrast in the retina. |
| Databáze: | OpenAIRE |
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